{"id":"W4312086344","doi":"10.1002/alz.067978","title":"Investigating the role of lysosomal exocytosis in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Exocytosis; Ionomycin; Lysosome; Cell biology; Secretion; LAMP1; Endosome; Secretory Vesicle; Synaptotagmin 1; Biology; Total internal reflection fluorescence microscope; Chemistry; Biochemistry; Intracellular; Synaptic vesicle; Vesicle; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004257042,0.0003785379,0.000397314,0.0005820745,0.0002371867,0.0007635429,0.0002133944,0.0004824994,0.000613552],"category_scores_gemma":[0.0001341429,0.0001429271,0.000415334,0.0002905429,0.0002629323,0.0006772023,0.0003177829,0.0004127245,0.0002239658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004674574,"about_ca_system_score_gemma":0.0002529207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005144591,"about_ca_topic_score_gemma":0.0002542099,"domain_scores_codex":[0.999881,0.00002178562,0.00001754018,0.00002411653,0.00002413279,0.00003143643],"domain_scores_gemma":[0.9999398,0.00001007438,0.00001252526,0.000005460633,0.00002031719,0.00001193531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001015259,0.0001666187,0.01015298,0.0008508957,0.000120134,0.001887971,0.0001520731,0.0004173535,0.9625317,0.001878397,0.0005793432,0.02024735],"study_design_scores_gemma":[0.0001342946,0.001089127,0.08140257,0.0001938088,0.00041204,0.01018297,0.0005958947,0.007540013,0.8709488,0.004018632,0.02343467,0.00004719662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9155173,0.07305598,0.006883032,0.0004966568,0.0001339729,0.0000734531,0.0004399413,0.00009557733,0.003304167],"genre_scores_gemma":[0.9711393,0.02365503,0.002829306,0.0001640115,0.00005477389,0.00004929018,0.0004072518,0.00001513749,0.001685927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007635429,"threshold_uncertainty_score":0.003391683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03701890534925952,"score_gpt":0.2994923958982345,"score_spread":0.262473490548975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}