{"id":"W4312086392","doi":"10.1002/alz.068973","title":"Update on the TOGETHER study: a patient‐ and investigator‐blind, randomized, placebo‐controlled study evaluating the efficacy, safety and tolerability of bepranemab, UCB0107, in prodromal‐to‐mild Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Placebo; Medicine; Clinical endpoint; Internal medicine; Adverse effect; Randomized controlled trial; Oncology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01326102,0.002410576,0.004589755,0.000673376,0.0009205596,0.001850984,0.001749708,0.004265406,0.007445497],"category_scores_gemma":[0.008879401,0.0009254991,0.004301462,0.0008541556,0.001257032,0.00232026,0.0007363682,0.004678504,0.001591584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005419124,"about_ca_system_score_gemma":0.002417004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007703681,"about_ca_topic_score_gemma":0.002254861,"domain_scores_codex":[0.9932862,0.004523787,0.0006051651,0.000619303,0.0007246768,0.0002408977],"domain_scores_gemma":[0.9939756,0.001697268,0.00152056,0.0006335176,0.001181444,0.000991606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8744406,0.006519133,0.002181954,0.007234589,0.009413581,0.0001641654,0.0002744636,0.0002596189,0.01343826,0.0006361583,0.01358733,0.07185007],"study_design_scores_gemma":[0.945365,0.03441836,0.00366288,0.000329518,0.003596847,0.00008770587,0.00004302014,0.0001343641,0.000729597,0.000200033,0.01139203,0.00004077154],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6892207,0.1196745,0.01073648,0.018301,0.01078871,0.08978337,0.0347956,0.001340293,0.02535932],"genre_scores_gemma":[0.7752054,0.04168757,0.02584239,0.02572149,0.007148227,0.08863336,0.01822791,0.0003766635,0.01715705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01326102,"threshold_uncertainty_score":0.07013184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05631332896207519,"score_gpt":0.3472837713793648,"score_spread":0.2909704424172896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}