{"id":"W4312086546","doi":"10.1002/alz.068847","title":"Plasma biomarkers associations with cognitive change in preclinical Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biomarker; Cognitive decline; Internal medicine; Cohort; Medicine; Oncology; Neuropsychology; Cognition; Effects of sleep deprivation on cognitive performance; Disease; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Psychology; Dementia; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006249392,0.0005306173,0.0004170421,0.00134371,0.0003108647,0.0007298012,0.0003445735,0.0006144392,0.001123507],"category_scores_gemma":[0.002479813,0.0001955967,0.0002853838,0.001135005,0.0002634764,0.0003483946,0.0003389573,0.0006427661,0.0002155138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070345,"about_ca_system_score_gemma":0.0002095034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00250609,"about_ca_topic_score_gemma":0.001455872,"domain_scores_codex":[0.9996275,0.00009508747,0.00005086972,0.0001067824,0.00007003765,0.00004970877],"domain_scores_gemma":[0.9983016,0.0003548756,0.000755345,0.0001421206,0.0002882745,0.0001577496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001047155,0.00008845598,0.9918683,0.00003231845,0.0001267143,0.0001203656,0.00007341262,0.0001303762,0.001849687,0.00003362271,0.0001589248,0.004470751],"study_design_scores_gemma":[0.00001050657,0.0001565313,0.9985678,0.000004706347,0.00003998122,0.0002189158,0.00003920682,0.0002207144,0.0004809682,0.00009114504,0.0001651181,0.000004375216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978435,0.0009757956,0.0001580314,0.00004016635,0.000007030068,0.000006065639,0.0004734804,0.00001597029,0.0004799835],"genre_scores_gemma":[0.9992843,0.00009212845,0.000162228,0.00001409728,0.00001174139,0.000005053981,0.0002748093,0.000002151844,0.0001534825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250609,"threshold_uncertainty_score":0.004983008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08677657309060466,"score_gpt":0.3731541754674809,"score_spread":0.2863776023768763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}