{"id":"W4312086640","doi":"10.1002/alz.067371","title":"Distinguishing between amyloid‐beta‐directed antibodies: Ability of PMN310 to target toxic oligomers despite competing species","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); University of British Columbia","funders":"","keywords":"Oligomer; Monomer; Antibody; Chemistry; Surface plasmon resonance; Amyloid (mycology); Amyloid beta; Fibril; Biochemistry; Biophysics; Peptide; Biology; Immunology; Polymer; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197749,0.0004213991,0.000215864,0.0001718258,0.0001338617,0.00023594,0.0001982953,0.0003288017,0.0009759839],"category_scores_gemma":[0.0003586315,0.0001382658,0.0001546094,0.0001262016,0.0001628567,0.0002223326,0.0001865684,0.0003245714,0.0002852352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161497,"about_ca_system_score_gemma":0.000161061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004066547,"about_ca_topic_score_gemma":0.0004597084,"domain_scores_codex":[0.9996995,0.00008031346,0.00002070289,0.00007166898,0.00007180307,0.00005594461],"domain_scores_gemma":[0.9997709,0.00008751747,0.00003901368,0.00002154667,0.00004367625,0.00003740455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001830723,0.0000435719,0.0004224763,0.0000353727,0.000005442025,0.00002583796,0.00001024342,0.0000579033,0.9972816,0.00003278098,0.00002245423,0.00187919],"study_design_scores_gemma":[0.00002751657,0.0008063259,0.005309671,0.000006902425,0.00001741133,0.0005126478,0.00001450388,0.001299543,0.9909816,0.0000572131,0.0009619323,0.000004727455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954641,0.0007028869,0.00282742,0.00002335092,0.000007308222,0.00002775821,0.00003622979,0.00002626672,0.000884619],"genre_scores_gemma":[0.9927407,0.0003225759,0.005453745,0.00005700051,0.000006545773,0.0000353873,0.0001504471,0.00001011388,0.00122355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009759839,"threshold_uncertainty_score":0.003265023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040717160805995,"score_gpt":0.3122793961754495,"score_spread":0.2715622353694545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}