{"id":"W4312086700","doi":"10.1002/alz.065584","title":"The Role of Sigma‐1‐Receptor in Endoreticulum Stress and Alzheimer's Disease.","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Unfolded protein response; Neuroprotection; Cell biology; Biology; Sigma-1 receptor; Receptor; Signal transduction; Endoplasmic reticulum; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452919,0.0001324019,0.0001166085,0.00002425184,0.0001981253,0.00001621961,0.000250603,0.00003689838,0.0002478723],"category_scores_gemma":[0.00002168092,0.0001052298,0.00006673462,0.00008076051,0.00009674904,0.000003886619,0.0004474225,0.000109737,0.000002514171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002249235,"about_ca_system_score_gemma":0.00003752658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002949153,"about_ca_topic_score_gemma":0.00001321436,"domain_scores_codex":[0.9989054,0.0001721892,0.0001908783,0.0002812122,0.0001803848,0.000269942],"domain_scores_gemma":[0.9995513,0.00003845578,0.00008386201,0.0001948971,0.00002290124,0.0001085687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004957872,0.0003976311,0.01721231,0.00000504328,0.003658694,0.000007716892,0.00009659382,0.0002729119,0.8731883,0.002872519,0.002030953,0.09976149],"study_design_scores_gemma":[0.0006812631,0.0004235815,0.004673046,0.000005382136,0.001704797,0.000001644626,0.0003112197,0.0003502913,0.8681774,0.0007176824,0.1227065,0.0002472264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.67852,0.3200254,0.00001896552,0.0001840341,0.0003426453,0.0004347992,0.00008944879,0.000009867267,0.0003748053],"genre_scores_gemma":[0.9987552,0.0006741093,0.00009278367,0.0001429121,0.0000571502,0.000180381,0.00007850304,0.00001504226,0.000003937774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3202352,"threshold_uncertainty_score":0.4291149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008269407938281365,"score_gpt":0.2427049183274063,"score_spread":0.234435510389125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}