{"id":"W4312086700","doi":"10.1002/alz.065584","title":"The Role of Sigma‐1‐Receptor in Endoreticulum Stress and Alzheimer's Disease.","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Unfolded protein response; Neuroprotection; Cell biology; Biology; Sigma-1 receptor; Receptor; Signal transduction; Endoplasmic reticulum; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774994,0.0003824691,0.0001961843,0.0002857551,0.0001058932,0.0001798708,0.0001354391,0.0002812082,0.001003571],"category_scores_gemma":[0.00006289748,0.00009147716,0.000234734,0.0001069319,0.0001585243,0.0001030185,0.0001321305,0.0003100354,0.0002534157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637355,"about_ca_system_score_gemma":0.0002190457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017709,"about_ca_topic_score_gemma":0.001528672,"domain_scores_codex":[0.9999441,0.00001353597,0.000006409581,0.00001241863,0.0000126099,0.00001091094],"domain_scores_gemma":[0.9999058,0.000008352935,0.00003783094,0.000004057961,0.00001579025,0.00002823022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002384735,0.0001898092,0.02131011,0.0009197351,0.0001701604,0.001763359,0.00008497378,0.0003840639,0.9188226,0.0009063538,0.001525418,0.05153859],"study_design_scores_gemma":[0.0003160957,0.003702778,0.5906751,0.0003983706,0.0004751195,0.008758392,0.0005627293,0.003380813,0.3535097,0.003483635,0.03467494,0.00006240984],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8087927,0.1827998,0.001820357,0.002427961,0.0002478554,0.00002898308,0.001004504,0.0001137874,0.002763964],"genre_scores_gemma":[0.961169,0.032375,0.001134938,0.0004035515,0.00008761746,0.00002062058,0.0009400184,0.000007774504,0.003861511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017709,"threshold_uncertainty_score":0.003357232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008269407938281365,"score_gpt":0.2427049183274063,"score_spread":0.234435510389125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}