{"id":"W4312087216","doi":"10.1002/alz.063749","title":"pTau heterogeneity as a measure for disease severity in incipient Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Neurofibrillary tangle; Tangle; Pathology; Cutoff; Dementia; Amyloid (mycology); Disease; Positron emission tomography; Medicine; Alzheimer's disease; Cerebrospinal fluid; Internal medicine; Psychology; Oncology; Nuclear medicine; Senile plaques; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000922825,0.00066084,0.0005555795,0.002400094,0.0004687982,0.0009784978,0.0004002477,0.0004742467,0.001876069],"category_scores_gemma":[0.0023169,0.0001603607,0.0004679126,0.001068399,0.000270982,0.0006471694,0.0006526019,0.0004226732,0.0002234121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855266,"about_ca_system_score_gemma":0.0001713026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825229,"about_ca_topic_score_gemma":0.00163021,"domain_scores_codex":[0.9996147,0.0000586906,0.00006877467,0.0001158947,0.0001033587,0.00003859297],"domain_scores_gemma":[0.9985529,0.0002504495,0.0007398126,0.00009319916,0.0001668341,0.0001967939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001159974,0.00006140904,0.9883956,0.00004825528,0.0002657493,0.0003207267,0.0001758389,0.000476757,0.002976803,0.0000865699,0.0002439576,0.005788456],"study_design_scores_gemma":[0.00001047924,0.0002524584,0.9954441,0.000009616833,0.0000755997,0.0007430782,0.0001631842,0.002194605,0.0006421392,0.0003074121,0.0001484819,0.000008936441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978735,0.0003736461,0.000475041,0.00003311749,0.0000100243,0.00002056131,0.0004178065,0.00002420519,0.0007720769],"genre_scores_gemma":[0.9993395,0.00003593346,0.0002606151,0.000004964824,0.000007744668,0.000009193408,0.0001840824,0.000002483308,0.000155439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002400094,"threshold_uncertainty_score":0.006276011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650138983196102,"score_gpt":0.3277065638667662,"score_spread":0.2812051740348052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}