{"id":"W4312087233","doi":"10.1002/alz.065731","title":"Apolipoprotein E ε4 associates with microglial activation in early Braak regions independently of amyloid‐β and tau","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Apolipoprotein E; Entorhinal cortex; Hippocampus; Dementia; Neuroscience; Psychology; Microglia; Amyloid (mycology); Pathology; Alzheimer's disease; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003626421,0.0007913871,0.0003999351,0.001175189,0.0005769842,0.0006946585,0.0003992589,0.0005570567,0.002640688],"category_scores_gemma":[0.0009714021,0.0004706646,0.0003612796,0.000594163,0.0005513603,0.0002375521,0.0003708442,0.0004167834,0.0003725972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647268,"about_ca_system_score_gemma":0.0002121338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006850029,"about_ca_topic_score_gemma":0.007576628,"domain_scores_codex":[0.9997569,0.00005262758,0.00002503984,0.00006449382,0.00004351237,0.00005748817],"domain_scores_gemma":[0.9989538,0.0001250176,0.0005802913,0.00008653208,0.0001138139,0.0001404513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005137634,0.0003628207,0.8862099,0.00006384493,0.0002563035,0.00441098,0.0005653907,0.0001116014,0.09841713,0.000139022,0.0003074049,0.004017854],"study_design_scores_gemma":[0.0000197553,0.0001512065,0.9962322,0.000006217656,0.00004328382,0.00177653,0.000132949,0.0001065676,0.001373731,0.00007144432,0.00007957347,0.000006549528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994824,0.00009874074,0.00008979291,0.00001810376,0.000003346025,0.000004841689,0.00004784029,0.000005831103,0.000249157],"genre_scores_gemma":[0.9994186,0.00003999464,0.0001106899,0.00001405416,0.000005554,0.000005201354,0.00006954439,0.000003996625,0.0003322298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006850029,"threshold_uncertainty_score":0.01362032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126044334234131,"score_gpt":0.2739684258666332,"score_spread":0.2527079825242919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}