{"id":"W4312087425","doi":"10.1002/alz.064811","title":"Longitudinal Blood Biomarker Trajectories in Preclinical Alzheimer’s Disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Biomarker; Positron emission tomography; Medicine; Cohort; Oncology; Internal medicine; Pathological; Standardized uptake value; Entorhinal cortex; Disease; Pathology; Nuclear medicine; Hippocampus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001126266,0.0002824159,0.0003552838,0.0005500477,0.0003849646,0.0005847638,0.0003172108,0.00043453,0.001122507],"category_scores_gemma":[0.002383815,0.0002387617,0.0002873279,0.0006084293,0.0001402733,0.0004146927,0.0004229429,0.0004967052,0.0002376489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214762,"about_ca_system_score_gemma":0.0002470887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003932328,"about_ca_topic_score_gemma":0.003209858,"domain_scores_codex":[0.9997018,0.00008788871,0.00002349384,0.000104204,0.00003742177,0.00004520315],"domain_scores_gemma":[0.9987187,0.0002606152,0.0004415311,0.0001687704,0.0002363718,0.0001740217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001049861,0.00009093035,0.9931073,0.00001005401,0.0001077614,0.00006815657,0.0001024724,0.0002275062,0.001265843,0.00005990307,0.0001516847,0.003758553],"study_design_scores_gemma":[0.00001272147,0.0003565269,0.9977514,0.000004475548,0.00005695336,0.0001202704,0.00006030086,0.0008792818,0.0003781048,0.0001567251,0.0002181504,0.000005082151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988862,0.0002077496,0.0002968862,0.00002545038,0.000002971423,0.000004402842,0.0004003693,0.000007960392,0.0001680313],"genre_scores_gemma":[0.9987808,0.00006596325,0.0002006444,0.00001301946,0.000003945871,0.000009528527,0.0007018886,0.00000234974,0.0002219864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003932328,"threshold_uncertainty_score":0.007818878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07940755159382118,"score_gpt":0.3663173868768363,"score_spread":0.2869098352830151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}