{"id":"W4312087534","doi":"10.1002/alz.064953","title":"Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University and Génome Québec Innovation Centre; University of Toronto; McGill University","funders":"","keywords":"Mendelian randomization; Genome-wide association study; Genetic association; Biology; Disease; Medicine; Bioinformatics; Genetics; Internal medicine; Gene; Genotype; Single-nucleotide polymorphism; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005542696,0.0003953795,0.0005646981,0.0008573168,0.0002033269,0.0009229374,0.0003256907,0.0004863386,0.001723088],"category_scores_gemma":[0.001129027,0.0002240431,0.0007028366,0.0009405934,0.0003198601,0.0004471609,0.0004594951,0.0005228188,0.0002135212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971672,"about_ca_system_score_gemma":0.0002157642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695124,"about_ca_topic_score_gemma":0.001611938,"domain_scores_codex":[0.9997273,0.00007317272,0.00001833665,0.0001110481,0.00003551566,0.00003459392],"domain_scores_gemma":[0.9992287,0.0002944426,0.0002511548,0.00009169558,0.00006895561,0.00006504076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002749186,0.0001437419,0.7876529,0.0009994409,0.004605182,0.001405981,0.0006717048,0.004550024,0.119508,0.003402595,0.002454076,0.07185715],"study_design_scores_gemma":[0.00005067243,0.0002024957,0.9836955,0.0001202064,0.0008647649,0.0006250273,0.0002091,0.002750694,0.003128366,0.005620297,0.002700976,0.00003194328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802265,0.009582621,0.006150349,0.0004946527,0.00004129432,0.00001145382,0.002147501,0.00007385065,0.001271645],"genre_scores_gemma":[0.9927273,0.002892449,0.002344185,0.0002333282,0.00005783539,0.00001814115,0.001139501,0.00002948179,0.000557831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723088,"threshold_uncertainty_score":0.005764306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02705647576413236,"score_gpt":0.2362259491017962,"score_spread":0.2091694733376638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}