{"id":"W4312087553","doi":"10.1002/alz.063883","title":"Macropinocytosis of APP is controlled by a cascade of regulatory proteins","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; Robarts Clinical Trials; Western University","funders":"","keywords":"Pinocytosis; RHOA; Membrane ruffling; Cell biology; Internalization; RAC1; CDC42; Endosome; Confocal microscopy; Confocal; Cell membrane; Live cell imaging; Chemistry; Small GTPase; Biology; Cell; Endocytosis; Intracellular; GTPase; Biochemistry; Signal transduction; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324855,0.0003488316,0.0002445541,0.0002091838,0.0002728329,0.0005985886,0.0001460733,0.0002054642,0.001165758],"category_scores_gemma":[0.0001387888,0.000158597,0.0002759663,0.0001166278,0.0002028707,0.0002508541,0.0003255463,0.0002497863,0.0005606856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460544,"about_ca_system_score_gemma":0.0001821905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003849769,"about_ca_topic_score_gemma":0.0002995903,"domain_scores_codex":[0.9998449,0.00001583866,0.000008805907,0.00004090968,0.00005461721,0.00003488362],"domain_scores_gemma":[0.9998908,0.00001576119,0.00003026652,0.000009027071,0.00002739293,0.00002667533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008481521,0.00001440291,0.0003928494,0.00003134556,0.000004251483,0.0001650259,0.00001539138,0.00008689224,0.9970582,0.0003162159,0.00009422272,0.001736444],"study_design_scores_gemma":[0.00004477442,0.0003273939,0.0505366,0.00002352035,0.00003518734,0.0008785183,0.00008314943,0.009327738,0.930965,0.0008130763,0.006937596,0.00002746856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838915,0.002259181,0.007913008,0.0001143021,0.00004320537,0.00005519414,0.000286902,0.0002841285,0.005152666],"genre_scores_gemma":[0.9924114,0.001132779,0.002515817,0.00005396552,0.00002658403,0.00008743177,0.0002693679,0.00002413561,0.003478641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165758,"threshold_uncertainty_score":0.003899813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180602637699233,"score_gpt":0.2895182246329517,"score_spread":0.2677121982559594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}