{"id":"W4312087585","doi":"10.1002/alz.066227","title":"Impact of meningeal and age‐related off‐target binding on longitudinal [<sup>18</sup>F]MK6240 quantification","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; McGill University","funders":"","keywords":"Bonferroni correction; Longitudinal study; Binding potential; Nuclear medicine; Medicine; Internal medicine; Pathology; Psychology; Positron emission tomography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002318275,0.00040633,0.0002387151,0.0006002383,0.0002309905,0.0005566232,0.0002338451,0.0003637608,0.001036247],"category_scores_gemma":[0.003831271,0.0002470088,0.0001432909,0.0002330716,0.0002983061,0.000375247,0.0003342034,0.0002258494,0.000195832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000382507,"about_ca_system_score_gemma":0.000179872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004098362,"about_ca_topic_score_gemma":0.004560188,"domain_scores_codex":[0.9991689,0.0003678733,0.00004646286,0.0001521918,0.0001847331,0.00007989333],"domain_scores_gemma":[0.9976448,0.001078563,0.0005561346,0.0002702399,0.0003474416,0.0001028423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006554082,0.0001803617,0.4140341,0.0002916721,0.0004743147,0.00155833,0.0006706238,0.002605824,0.5029315,0.0004603024,0.0004009128,0.06983798],"study_design_scores_gemma":[0.00001798392,0.001368393,0.7963665,0.00004867746,0.0003492705,0.002902324,0.0001802151,0.01068081,0.1859771,0.000289053,0.001789373,0.00003029161],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936885,0.001595009,0.003538138,0.00002238424,0.00001196652,0.000009390514,0.0001116902,0.00003367892,0.0009893961],"genre_scores_gemma":[0.998254,0.0001916939,0.001157942,0.00001571138,0.000004685779,0.000008894904,0.00005417008,0.00002212539,0.0002907142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004098362,"threshold_uncertainty_score":0.01226038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05946841140329558,"score_gpt":0.3499113995032073,"score_spread":0.2904429880999118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}