{"id":"W4312088112","doi":"10.1002/alz.061927","title":"sTREM2 affects cytokine expression profiles in THP‐1 cell model.","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Ottawa","funders":"","keywords":"THP1 cell line; Cytokine; Inflammation; Chemokine; Monoclonal antibody; Proinflammatory cytokine; Innate immune system; Macrophage; Tumor necrosis factor alpha; Cell biology; Immunology; Immune system; Antibody; Cell culture; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239214,0.0004289845,0.0003915596,0.0002591592,0.000164231,0.0002438919,0.0001411481,0.000427893,0.002020424],"category_scores_gemma":[0.0001419929,0.000150591,0.0003599184,0.0002282095,0.0001890729,0.0001891623,0.0001369261,0.0008481434,0.0007052842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138704,"about_ca_system_score_gemma":0.0001600201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003054505,"about_ca_topic_score_gemma":0.00058947,"domain_scores_codex":[0.9997754,0.0000467653,0.00002479332,0.00003944039,0.00005628409,0.00005737372],"domain_scores_gemma":[0.9998879,0.00001753356,0.00002494157,0.00001241569,0.00002579253,0.00003143812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005731928,0.0001060034,0.0002216213,0.000145309,0.000007622733,0.0001365471,0.00003179406,0.00008067372,0.9973226,0.00004328196,0.0002795129,0.00105188],"study_design_scores_gemma":[0.00007531965,0.001667689,0.007081155,0.00002253835,0.00003474758,0.0005609157,0.0001485236,0.001195511,0.9835845,0.0000868733,0.005529183,0.00001312596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816506,0.005078551,0.004018791,0.0005636286,0.0004048144,0.0001250035,0.004270148,0.0001935446,0.003694922],"genre_scores_gemma":[0.9742768,0.002751728,0.008545534,0.0005098014,0.0001236365,0.0003847676,0.004579016,0.00003876325,0.00878981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020424,"threshold_uncertainty_score":0.006758988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803196376606857,"score_gpt":0.2249112715839714,"score_spread":0.2068793078179028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}