{"id":"W4312088112","doi":"10.1002/alz.061927","title":"sTREM2 affects cytokine expression profiles in THP‐1 cell model.","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Ottawa","funders":"","keywords":"THP1 cell line; Cytokine; Inflammation; Chemokine; Monoclonal antibody; Proinflammatory cytokine; Innate immune system; Macrophage; Tumor necrosis factor alpha; Cell biology; Immunology; Immune system; Antibody; Cell culture; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002788854,0.0001516014,0.0001570169,0.0001238778,0.000297567,0.00001114646,0.0002203261,0.00009043176,0.002371471],"category_scores_gemma":[0.000003826141,0.0001456245,0.00006376403,0.000130585,0.00004200602,0.00009430312,0.0002492526,0.000233652,0.0001535092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008165496,"about_ca_system_score_gemma":0.00004894867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003713215,"about_ca_topic_score_gemma":0.00001651916,"domain_scores_codex":[0.99889,0.0002305287,0.0002282157,0.0002781029,0.00006107755,0.0003120253],"domain_scores_gemma":[0.9995739,0.00003533889,0.0001162823,0.0002399595,0.00001818503,0.00001636442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001426017,0.0001792217,0.002839712,0.00000510295,0.0006086421,0.00001244378,0.0005861467,0.0008221196,0.9686961,0.000478718,0.02162652,0.004002731],"study_design_scores_gemma":[0.001375457,0.0001195432,0.001497364,0.000009435095,0.0005471153,0.000008974822,0.0002254429,0.0006204917,0.9637514,0.0002049334,0.03138522,0.0002546532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9048615,0.07844072,0.0003894458,0.0002610482,0.001264713,0.0009533284,0.0002051486,0.0001519855,0.01347217],"genre_scores_gemma":[0.9986521,0.00002447674,0.0004246026,0.0001415471,0.0000162339,0.0001592081,0.000419429,0.00001722317,0.0001451816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09379066,"threshold_uncertainty_score":0.9985405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803196376606857,"score_gpt":0.2249112715839714,"score_spread":0.2068793078179028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}