{"id":"W4312088313","doi":"10.1002/alz.059695","title":"Translational profiling identifies sex‐specific metabolic and epigenetic reprogramming of microglia in cerebral amyloidosis models with an antibiotic‐altered gut microbiome","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; Microglia; Phenotype; Microbiome; Genetically modified mouse; Epigenetics; Transgene; Immunology; Cell biology; Inflammation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753327,0.0003539532,0.0003561088,0.0005051875,0.0002440019,0.0003861468,0.0001441435,0.0003338388,0.001505831],"category_scores_gemma":[0.000127249,0.0001849196,0.0003685366,0.0002384041,0.0002441858,0.0002124036,0.0002469681,0.0006140595,0.0003207031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071151,"about_ca_system_score_gemma":0.0002023149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004388707,"about_ca_topic_score_gemma":0.0009037753,"domain_scores_codex":[0.9997879,0.00002325705,0.0000140694,0.0000673608,0.00004829008,0.00005913696],"domain_scores_gemma":[0.9998451,0.000007789781,0.00006636999,0.00001319077,0.00003190623,0.0000354708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008164393,0.00007071261,0.004338502,0.00007064966,0.00002966313,0.0001039315,0.00006818203,0.00002698284,0.9912099,0.00005883329,0.0001350306,0.003071128],"study_design_scores_gemma":[0.00005716892,0.001531625,0.2660258,0.00006370129,0.0002170122,0.0009648342,0.000578536,0.001039715,0.723494,0.0003342433,0.005652434,0.00004095329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914636,0.002411402,0.002764682,0.0001419892,0.00006483865,0.00004440658,0.001998089,0.00007944622,0.001031509],"genre_scores_gemma":[0.9901068,0.001991143,0.001990543,0.0001859891,0.00003281272,0.0002466687,0.001653716,0.00005863503,0.003733734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505831,"threshold_uncertainty_score":0.005037487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0479770650093547,"score_gpt":0.2598835246726749,"score_spread":0.2119064596633202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}