{"id":"W4312088388","doi":"10.1002/alz.060740","title":"The role of IGFBP2 in pre‐symptomatic Alzheimer's disease: a multimodal longitudinal study of cognitively unaffected individuals with a family history of sporadic Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alzheimer Society of Canada; McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Psychology; Cohort; Cognitive reserve; Alzheimer's disease; Oncology; Alzheimer's Disease Neuroimaging Initiative; Repeatable Battery for the Assessment of Neuropsychological Status; Neuropsychology; Cognition; Neuropathology; Frontotemporal lobar degeneration; Internal medicine; Disease; Neuroscience; Medicine; Dementia; Cognitive impairment; Frontotemporal dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006071748,0.0004662743,0.0003172014,0.0009377273,0.001080048,0.000673205,0.0004115361,0.0005915772,0.001458054],"category_scores_gemma":[0.001535159,0.0003557278,0.0004597243,0.0009631136,0.0002975474,0.0004219448,0.0004314213,0.0005573698,0.0002453676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345652,"about_ca_system_score_gemma":0.0003423491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01798879,"about_ca_topic_score_gemma":0.01633143,"domain_scores_codex":[0.9997049,0.0000694646,0.00002360193,0.00009284652,0.00005740443,0.00005166943],"domain_scores_gemma":[0.9994118,0.00007867577,0.0002153755,0.00005943671,0.0001025727,0.0001320865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002328271,0.0001024104,0.9974618,0.000006233046,0.00007596658,0.0002651155,0.000280649,0.00001547233,0.000618169,0.00001278743,0.00006588544,0.0008627031],"study_design_scores_gemma":[0.000005460085,0.000077303,0.9993123,0.000002237139,0.00002789623,0.0002577472,0.0001420897,0.00006539476,0.00003530617,0.00001456049,0.00005778006,0.000001992837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995829,0.00009451366,0.00003552056,0.00001649448,0.00000291491,0.000003096618,0.0001129347,0.000001519542,0.0001501009],"genre_scores_gemma":[0.9996244,0.00003904458,0.0000474723,0.00001463273,0.000003645032,0.000004877067,0.0001220059,9.955872e-7,0.0001428366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01798879,"threshold_uncertainty_score":0.03576821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497485656625281,"score_gpt":0.2604840185279068,"score_spread":0.2355091619616539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}