{"id":"W4312088487","doi":"10.1002/alz.061094","title":"Ubiquitin‐proteasome system dysfunction induced by Alzheimer's disease‐linked Ab oligomers","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hippocampal formation; Proteasome; Ubiquitin; Proteolysis; Synaptosome; Alzheimer's disease; Oxidative stress; Neuroscience; Synapse; Chemistry; Synaptic plasticity; Biology; Endocrinology; Cell biology; Internal medicine; Medicine; Biochemistry; Enzyme; Disease; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580649,0.0005892448,0.0003456501,0.0003311106,0.0002314372,0.0003464601,0.0001469551,0.000318849,0.001121364],"category_scores_gemma":[0.0000874693,0.0001526938,0.0002511432,0.0001626041,0.000282871,0.0001831244,0.0001660295,0.0005316082,0.0002576156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776143,"about_ca_system_score_gemma":0.0001761284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004303289,"about_ca_topic_score_gemma":0.0004195767,"domain_scores_codex":[0.9999046,0.00001083088,0.00001316836,0.0000215095,0.00001746821,0.00003240613],"domain_scores_gemma":[0.9999166,0.000007650538,0.00002769294,0.000007648947,0.00001209781,0.00002849373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006832868,0.0001612862,0.0009940788,0.0001004308,0.00002593507,0.0001932364,0.0000191421,0.00003550677,0.9963773,0.00008142833,0.00006949394,0.001258892],"study_design_scores_gemma":[0.0000870033,0.001727294,0.03783021,0.00002364311,0.00007704186,0.001099871,0.00008147881,0.0007761963,0.9569846,0.0002325633,0.001071612,0.000008467773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968185,0.001771435,0.0005657845,0.00003412869,0.00002806067,0.00001638433,0.0001664805,0.00002668755,0.000572468],"genre_scores_gemma":[0.997934,0.0007723796,0.000397005,0.00003193825,0.000009459702,0.0000247596,0.0001748599,0.000003661799,0.0006519156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121364,"threshold_uncertainty_score":0.003751338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081719571725821,"score_gpt":0.2843257689483485,"score_spread":0.2535085732310903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}