{"id":"W4312088573","doi":"10.1002/alz.059761","title":"Attenuation of translational repression rescues memory impairment in Alzheimer`s disease mice","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; McGill University; Queen's University","funders":"","keywords":"Protein biosynthesis; Hippocampal formation; Memory consolidation; Neuroscience; Anisomycin; Amyloid precursor protein; Fragile X syndrome; Genetically modified mouse; Translation (biology); Translational regulation; Messenger RNA; Memory impairment; EIF4E; Biology; Alzheimer's disease; Molecular biology; Transgene; Medicine; Hippocampus; Genetics; Internal medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115488,0.001124014,0.0005002045,0.0006046399,0.0002251584,0.0003491685,0.0004903051,0.0005680223,0.002002498],"category_scores_gemma":[0.0001178594,0.0003031829,0.0004074628,0.0001888189,0.0003600931,0.0002077515,0.0002808765,0.001095464,0.0007586936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003023449,"about_ca_system_score_gemma":0.0003172994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006246694,"about_ca_topic_score_gemma":0.0009415954,"domain_scores_codex":[0.9998287,0.0000183621,0.00002058137,0.00004342852,0.00004404952,0.0000447903],"domain_scores_gemma":[0.999723,0.00002178561,0.0001106826,0.00003932701,0.00002254869,0.0000826727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001789942,0.0001020339,0.00007325179,0.00003081642,0.000007177598,0.00004075856,0.000009758014,0.00003990162,0.9984217,0.00007800202,0.00005485024,0.0009628179],"study_design_scores_gemma":[0.0001281032,0.001367178,0.003561954,0.00002563092,0.00004493757,0.0002501178,0.00002418545,0.0007700652,0.9902352,0.000125002,0.003455137,0.00001248796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919662,0.001199516,0.003496914,0.0002020458,0.00008336511,0.00005554701,0.0008859478,0.0005327194,0.001577729],"genre_scores_gemma":[0.9815428,0.001614938,0.00491765,0.0001872475,0.00005101897,0.0001702234,0.001620261,0.0001977977,0.009698159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002498,"threshold_uncertainty_score":0.006699026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620818565831758,"score_gpt":0.2539641290539833,"score_spread":0.2377559433956657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}