{"id":"W4312088577","doi":"10.1002/alz.059663","title":"A Placebo‐Controlled Phase I Study in Healthy Subjects Assessing NVG‐291, which Targets CNS Receptor Protein Tyrosine Phosphatase Sigma (PTPσ)","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cardiome (Canada)","funders":"","keywords":"Medicine; Placebo; Tolerability; Protein tyrosine phosphatase; Remyelination; Multiple sclerosis; Pharmacology; Biomarker; Internal medicine; Oncology; Receptor; Central nervous system; Adverse effect; Pathology; Chemistry; Immunology; Myelin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002035203,0.00167584,0.002624126,0.0004715815,0.0007718469,0.0007859973,0.0009580823,0.00192808,0.006428821],"category_scores_gemma":[0.001150099,0.0007673841,0.001030007,0.0003162234,0.001330384,0.0008202244,0.0003787933,0.002373788,0.001254474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772716,"about_ca_system_score_gemma":0.001901314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116573,"about_ca_topic_score_gemma":0.002685221,"domain_scores_codex":[0.999293,0.0002851149,0.00004381783,0.0001723119,0.00007012153,0.0001355247],"domain_scores_gemma":[0.9990607,0.0001484074,0.000141985,0.00007597857,0.0001254088,0.0004475472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.906124,0.04875798,0.001205354,0.0006992403,0.0006116907,0.00009403965,0.00009947212,0.0002572788,0.02033459,0.000117383,0.001532891,0.02016605],"study_design_scores_gemma":[0.5220068,0.4713087,0.00386389,0.00002121585,0.000214169,0.00003672292,0.00003524069,0.0001869189,0.0008150378,0.0001555652,0.001341556,0.00001417908],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961964,0.005532661,0.001977775,0.0007168267,0.0008548087,0.02291415,0.002630955,0.000215959,0.003192945],"genre_scores_gemma":[0.9558012,0.003202015,0.004535708,0.00216099,0.0007045764,0.02357453,0.002021666,0.00003700581,0.007962123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006428821,"threshold_uncertainty_score":0.02150649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063903342122537,"score_gpt":0.3164653154161309,"score_spread":0.2958262819949056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}