{"id":"W4312088577","doi":"10.1002/alz.059663","title":"A Placebo‐Controlled Phase I Study in Healthy Subjects Assessing NVG‐291, which Targets CNS Receptor Protein Tyrosine Phosphatase Sigma (PTPσ)","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cardiome (Canada)","funders":"","keywords":"Medicine; Placebo; Tolerability; Protein tyrosine phosphatase; Remyelination; Multiple sclerosis; Pharmacology; Biomarker; Internal medicine; Oncology; Receptor; Central nervous system; Adverse effect; Pathology; Chemistry; Immunology; Myelin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001028152,0.0003886531,0.0004625704,0.000189729,0.0005645622,0.0001207216,0.0004317972,0.0001056176,0.001059406],"category_scores_gemma":[0.0002160364,0.0004214778,0.0001437116,0.0004753857,0.00004503678,0.00003877623,0.0004817588,0.000465934,0.0000343991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004303033,"about_ca_system_score_gemma":0.0003817632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134576,"about_ca_topic_score_gemma":0.0005651711,"domain_scores_codex":[0.9964792,0.0007611439,0.0007462213,0.0009144247,0.0004325534,0.0006664774],"domain_scores_gemma":[0.9985338,0.00004350379,0.0003726171,0.0007177258,0.0001545637,0.0001777935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0256076,0.01337246,0.005046113,0.00002872536,0.01415833,0.0001576475,0.0008847286,0.00056228,0.9118871,0.00009524192,0.01656349,0.0116363],"study_design_scores_gemma":[0.09260609,0.01116356,0.001193926,0.00006236674,0.005145234,0.00005354449,0.003036434,0.000821006,0.794578,0.00005991745,0.08950163,0.001778363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283546,0.06306744,0.0004420074,0.0009070667,0.000839602,0.00581073,0.0001530703,0.00006262825,0.0003628797],"genre_scores_gemma":[0.9929489,0.00003127614,0.001419715,0.0003575483,0.0002015411,0.004188109,0.0007091756,0.00007869005,0.00006497519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1173092,"threshold_uncertainty_score":0.9998538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063903342122537,"score_gpt":0.3164653154161309,"score_spread":0.2958262819949056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}