{"id":"W4312089822","doi":"10.7554/elife.74433","title":"Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Cancer Research Society; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; W. M. Keck Foundation","keywords":"Microvesicles; Metastasis; Cancer cell; Biology; Cancer research; Cell migration; Microvesicle; Stromal cell; Tumor microenvironment; Invadopodia; Intravasation; Cancer-Associated Fibroblasts; Cancer; Cell; Cell biology; Primary tumor; microRNA; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105997,0.0002407039,0.0001374233,0.0001067591,0.00009254556,0.0002510721,0.00009138823,0.0002069958,0.0007394066],"category_scores_gemma":[0.00006937627,0.00008759266,0.0001907608,0.00007045238,0.0001022485,0.0001669685,0.000185599,0.0004149851,0.0002091507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162199,"about_ca_system_score_gemma":0.0001252127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005124002,"about_ca_topic_score_gemma":0.001050067,"domain_scores_codex":[0.9999263,0.00001507306,0.000004890111,0.00001314438,0.00001828609,0.00002231624],"domain_scores_gemma":[0.999965,0.000008927927,0.000008123591,0.000003525664,0.000004000816,0.00001044778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000190719,0.00000605695,0.00009129717,0.00000970286,0.000001378754,0.00003794221,0.00000750329,0.00002578593,0.9992241,0.00008449223,0.00001906923,0.0004735877],"study_design_scores_gemma":[0.00001369516,0.000150017,0.002419817,0.000004486948,0.000007536241,0.0003175499,0.00003040392,0.0008510923,0.9934895,0.00006373113,0.002648589,0.000003475716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884068,0.001149091,0.007976607,0.000162347,0.0000239562,0.00005407862,0.0001529777,0.00006773159,0.002006336],"genre_scores_gemma":[0.9920976,0.0006669322,0.003542659,0.0000647925,0.000007170053,0.00002495397,0.0001587373,0.00001233517,0.003424823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007394066,"threshold_uncertainty_score":0.002473533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140931188246186,"score_gpt":0.2538753990086279,"score_spread":0.242466087126166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}