{"id":"W4312094134","doi":"10.1056/nejmoa2208470","title":"Sotorasib in <i>KRAS</i> p.G12C–Mutated Advanced Pancreatic Cancer","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":468,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; Memorial Sloan-Kettering Cancer Center; Cancer Prevention and Research Institute of Texas; Amgen","keywords":"KRAS; Pancreatic cancer; Medicine; Mutation; Pancreas; Cancer; Cancer research; Internal medicine; Biology; Genetics; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379288,0.0005429636,0.00124639,0.0004159959,0.0001546157,0.000483213,0.000285775,0.0004064218,0.001200729],"category_scores_gemma":[0.0009741283,0.0001647954,0.0008837512,0.0004435033,0.00030337,0.0004166821,0.0002443646,0.0009322322,0.0001954368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005295767,"about_ca_system_score_gemma":0.0005436609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311052,"about_ca_topic_score_gemma":0.001114014,"domain_scores_codex":[0.9996172,0.0001999124,0.00004057759,0.00005167988,0.00005197545,0.00003858508],"domain_scores_gemma":[0.9995556,0.0001339842,0.0001418815,0.00003164011,0.00004096139,0.00009581769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2723548,0.005677687,0.03360936,0.003494154,0.008097134,0.001115927,0.0002941704,0.006187128,0.08026197,0.0005153003,0.007238651,0.5811538],"study_design_scores_gemma":[0.2033355,0.5183143,0.1752617,0.001202368,0.01398584,0.006090826,0.0003400285,0.006665322,0.037363,0.00135241,0.03597295,0.00011577],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658225,0.02925633,0.0009951023,0.0007690538,0.0001209824,0.0004485667,0.0003058866,0.00005532711,0.00222618],"genre_scores_gemma":[0.9859555,0.01117136,0.0008761393,0.0004695452,0.0001949814,0.0003191666,0.0005255422,0.00001450306,0.0004731403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379288,"threshold_uncertainty_score":0.007294416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978042101672789,"score_gpt":0.3606203463971002,"score_spread":0.3308399253803723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}