{"id":"W4312094134","doi":"10.1056/nejmoa2208470","title":"Sotorasib in <i>KRAS</i> p.G12C–Mutated Advanced Pancreatic Cancer","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":468,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; Memorial Sloan-Kettering Cancer Center; Cancer Prevention and Research Institute of Texas; Amgen","keywords":"KRAS; Pancreatic cancer; Medicine; Mutation; Pancreas; Cancer; Cancer research; Internal medicine; Biology; Genetics; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001766305,0.0001661332,0.00105345,0.0004311364,0.00009392908,0.000003839558,0.0001893731,0.00005256989,0.00354846],"category_scores_gemma":[0.0007026225,0.0001126107,0.00007726675,0.0005549025,0.0001335938,0.00007451105,0.00005367078,0.001014546,0.000004719288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003875884,"about_ca_system_score_gemma":0.001135225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006791796,"about_ca_topic_score_gemma":0.0001145793,"domain_scores_codex":[0.9975083,0.0003000918,0.0007666132,0.0001663652,0.0009010877,0.0003574731],"domain_scores_gemma":[0.9984098,0.0004828713,0.0003307172,0.0001849749,0.0001862363,0.0004053634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009170814,0.0004313715,0.8122846,0.0001383903,0.0003955301,0.004477667,0.0040114,0.0004262417,0.0160046,0.0001082079,0.03132162,0.1212295],"study_design_scores_gemma":[0.3374356,0.01747958,0.3608169,0.001869188,0.001494651,0.01080851,0.004473368,0.001172838,0.0006373627,0.002222051,0.261158,0.0004319403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685082,0.007305368,0.0001102707,0.01949596,0.000589388,0.000351937,0.000004614365,0.00001297837,0.003621226],"genre_scores_gemma":[0.9905013,0.002170722,0.0005615623,0.001669768,0.001660731,0.00002718152,0.00001013696,0.00002378056,0.003374825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4514678,"threshold_uncertainty_score":0.9973624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02978042101672789,"score_gpt":0.3606203463971002,"score_spread":0.3308399253803723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}