{"id":"W4312094178","doi":"10.1007/s40121-022-00744-3","title":"Final Results from a Phase 2b Randomized, Placebo-Controlled Clinical Trial of RBX2660: A Microbiota-Based Drug for the Prevention of Recurrent Clostridioides difficile Infection","year":2022,"lang":"en","type":"article","venue":"Infectious Diseases and Therapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Medicine; Placebo; Adverse effect; Clostridioides; Clinical endpoint; Diarrhea; Clinical trial; Internal medicine; Randomized controlled trial; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005912501,0.002163252,0.003301015,0.0004600525,0.0008251498,0.001244924,0.0008883169,0.002708044,0.01136168],"category_scores_gemma":[0.003706496,0.0007809838,0.002061673,0.0004160782,0.0009942368,0.001013106,0.0003823251,0.003226133,0.00169432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004618318,"about_ca_system_score_gemma":0.00175569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000413146,"about_ca_topic_score_gemma":0.001054767,"domain_scores_codex":[0.9981391,0.001046462,0.0001612448,0.0002632988,0.0001853396,0.0002045179],"domain_scores_gemma":[0.9976416,0.0006482463,0.0006394609,0.0002092891,0.000365829,0.0004956006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.960454,0.009004852,0.0006507069,0.001257667,0.001209365,0.00006912337,0.00005109832,0.0003163888,0.007374073,0.0001518043,0.002780443,0.0166805],"study_design_scores_gemma":[0.9004773,0.09393269,0.002095113,0.00007657965,0.0007603162,0.00004925801,0.00001499487,0.0001480849,0.0009427925,0.0001614552,0.001324167,0.00001713762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9192166,0.01345722,0.004135942,0.003328869,0.001627785,0.03528151,0.01327023,0.0005501444,0.009131698],"genre_scores_gemma":[0.9304789,0.007499362,0.008349126,0.004887953,0.001173958,0.02924429,0.008902312,0.0001325215,0.009331536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01136168,"threshold_uncertainty_score":0.03800863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05143402693711697,"score_gpt":0.374730222216516,"score_spread":0.3232961952793991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}