{"id":"W4312094178","doi":"10.1007/s40121-022-00744-3","title":"Final Results from a Phase 2b Randomized, Placebo-Controlled Clinical Trial of RBX2660: A Microbiota-Based Drug for the Prevention of Recurrent Clostridioides difficile Infection","year":2022,"lang":"en","type":"article","venue":"Infectious Diseases and Therapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Medicine; Placebo; Adverse effect; Clostridioides; Clinical endpoint; Diarrhea; Clinical trial; Internal medicine; Randomized controlled trial; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001893661,0.0002566273,0.001285971,0.0001990479,0.0003275743,0.00003259529,0.0001152771,0.00008192411,0.0001846608],"category_scores_gemma":[0.001358935,0.0001735813,0.001369716,0.0002913828,0.0003202787,0.00003780599,0.00006160622,0.0003380274,7.856776e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000883573,"about_ca_system_score_gemma":0.0005220337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007331728,"about_ca_topic_score_gemma":0.00002749508,"domain_scores_codex":[0.9965634,0.0009226437,0.001342968,0.0004468142,0.0004593645,0.000264814],"domain_scores_gemma":[0.9933389,0.005110607,0.0007391211,0.0004255149,0.0002491459,0.0001367372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9235035,0.008792681,0.0003770628,0.00006477609,0.001000654,0.000003100479,0.0001056261,0.0001548217,0.002912486,0.0000291393,0.0008302151,0.06222591],"study_design_scores_gemma":[0.9732667,0.0105012,0.0002862963,0.00008296368,0.001079195,0.000005163869,0.00007594533,0.005339236,0.006015755,0.0002541153,0.002926547,0.0001668596],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839826,0.005117051,0.0002998175,0.0005022584,0.0006705602,0.007740826,0.001592515,0.00004716565,0.00004719976],"genre_scores_gemma":[0.9929665,0.004378398,0.00001699608,0.0000667288,0.0004973928,0.001530905,0.0004098841,0.00002900096,0.0001041922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06205905,"threshold_uncertainty_score":0.707844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05143402693711697,"score_gpt":0.374730222216516,"score_spread":0.3232961952793991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}