{"id":"W4312094510","doi":"10.1002/cam4.5515","title":"Genetic testing women with newly diagnosed breast cancer: What criteria are the most predictive of a positive test?","year":2022,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Mount Sinai Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; Women's College Hospital","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; PALB2; Genetic testing; Family history; Medicine; CHEK2; Cancer; Oncology; Mammography; Internal medicine; Gynecology; Genetics; Gene; Mutation; Germline mutation; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716753,0.0001903352,0.0002370144,0.0000486569,0.0002318063,0.00001571516,0.0003185621,0.00004362987,0.0003706572],"category_scores_gemma":[0.0001247995,0.0001341595,0.00002150022,0.0004945844,0.0004060566,0.000009532849,0.000167256,0.0001710006,3.311192e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000399431,"about_ca_system_score_gemma":0.0006980303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006849185,"about_ca_topic_score_gemma":0.0001682274,"domain_scores_codex":[0.9986554,0.00009401521,0.0002421461,0.0003995386,0.000315608,0.0002933207],"domain_scores_gemma":[0.9987578,0.0001255224,0.0002714564,0.0003838096,0.0003720167,0.00008940668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002384468,0.000321979,0.2396718,0.000228363,0.001078003,0.0001026905,0.0159237,0.03720415,0.5142835,0.000007605242,0.03372881,0.1550649],"study_design_scores_gemma":[0.0071388,0.005550562,0.8870281,0.001293094,0.0004589299,0.0003971802,0.06102382,0.001689528,0.02272269,0.0001046569,0.01183879,0.0007538637],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753764,0.01615687,0.0002424312,0.005849669,0.0005872581,0.0005779499,0.0009833875,0.00001678216,0.0002092007],"genre_scores_gemma":[0.9931566,0.00133938,0.0001618075,0.002410214,0.0008583876,0.001865131,0.0000385751,0.00004152226,0.0001284552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6473563,"threshold_uncertainty_score":0.5470865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004475453486142,"score_gpt":0.2669236427494616,"score_spread":0.2568788882146001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}