{"id":"W4312095146","doi":"10.3324/haematol.2022.280482","title":"Adjusted comparison of outcomes between patients from CARTITUDE-1 <i>versus</i> multiple myeloma patients with prior exposure to proteasome inhibitors, immunomodulatory drugs and anti-CD38 antibody from the prospective, multinational LocoMMotion study of real-world clinical practice","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Legend Biotech","keywords":"Medicine; Hazard ratio; Internal medicine; Multiple myeloma; Confidence interval; Dexamethasone; Gastroenterology; Pomalidomide; Cyclophosphamide; Proportional hazards model; Oncology; Bortezomib; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005800922,0.000385671,0.001382229,0.0002001933,0.0004557333,0.00002800811,0.0003326024,0.0001137714,0.00006069554],"category_scores_gemma":[0.001739421,0.0002524744,0.0001435416,0.0005125401,0.0002421514,0.0002217459,0.0006175081,0.0005083961,0.000006824445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942948,"about_ca_system_score_gemma":0.0001379571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065969,"about_ca_topic_score_gemma":0.0005784699,"domain_scores_codex":[0.9945953,0.00111451,0.001316673,0.0007892742,0.001795647,0.0003885883],"domain_scores_gemma":[0.9943959,0.002719603,0.001042006,0.0007428356,0.0008628663,0.0002368199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005973786,0.01345621,0.9723786,0.00004284441,0.001346844,0.00002358285,0.003004114,0.00002216934,0.0002453303,0.00001741053,0.0001191027,0.003370019],"study_design_scores_gemma":[0.02860738,0.006997561,0.96155,0.0001037785,0.0004432816,6.275961e-7,0.001508354,0.00006796819,0.0003271964,0.000005363443,0.0001642927,0.0002241858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908847,0.000140865,0.000009480077,0.0002186005,0.0001671176,0.007690969,0.0007523683,0.00005970365,0.000076264],"genre_scores_gemma":[0.9962553,0.000006936218,0.001911254,0.00003146726,0.00004757206,0.000447793,0.001241738,0.00003919901,0.00001869057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0226336,"threshold_uncertainty_score":0.9999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03679352061212361,"score_gpt":0.3502240453261489,"score_spread":0.3134305247140253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}