{"id":"W4312102277","doi":"10.21203/rs.3.rs-2352174/v1","title":"In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Cancer Society Research Institute; Terry Fox Research Institute; University of Toronto; Government of Ontario; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Fondation Brain Canada; McGill University","keywords":"CRISPR; Pancreatic cancer; Cancer research; In vivo; Biology; Mutagenesis; Cancer; Suppressor; Mutation; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003330342,0.0005783673,0.0003988614,0.0005327648,0.0002676318,0.000864033,0.0005697914,0.000922984,0.003480519],"category_scores_gemma":[0.0003454412,0.0003789071,0.0004400797,0.0003434681,0.0004109128,0.0003238453,0.0006389368,0.001125486,0.0009092072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503241,"about_ca_system_score_gemma":0.0002770905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000889848,"about_ca_topic_score_gemma":0.001818144,"domain_scores_codex":[0.9996953,0.00003076027,0.00002384062,0.00009186429,0.0001166494,0.00004161313],"domain_scores_gemma":[0.9997301,0.00008632695,0.00006456157,0.00005104329,0.00001239777,0.00005560722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007891874,0.00001514272,0.0005139916,0.00003256963,0.00001693371,0.0002223287,0.00001876736,0.0002607379,0.993578,0.001174462,0.0002422445,0.003846016],"study_design_scores_gemma":[0.00001908228,0.00004020257,0.003094749,0.000006457858,0.0000364011,0.0006250023,0.00002509757,0.002477874,0.986863,0.0005299421,0.006272493,0.000009802794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9170446,0.002192169,0.0625122,0.0008086555,0.0001907967,0.00007945408,0.003978211,0.002343906,0.01085008],"genre_scores_gemma":[0.9731102,0.0008085555,0.01658003,0.0001470629,0.00001654884,0.00003063364,0.001102234,0.0003689888,0.007835704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003480519,"threshold_uncertainty_score":0.01164353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04886965313252977,"score_gpt":0.4107841969105797,"score_spread":0.3619145437780499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}