{"id":"W4312102317","doi":"10.21203/rs.3.rs-2395118/v1","title":"The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Prevention of Organ Failure; St. Paul's Hospital","funders":"National Institute of Allergy and Infectious Diseases; Mitacs; National Institutes of Health; Moderna; International AIDS Vaccine Initiative","keywords":"Immunogenicity; Chemokine; In vivo; In vitro; Messenger RNA; Immunology; CXCL10; Medicine; Immune system; Biology; Virology; Gene; Biotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.008697028,0.0004424448,0.0008789783,0.001860998,0.0005162357,0.0002417445,0.001060599,0.000468454,0.00009490654],"category_scores_gemma":[0.002350892,0.0003632112,0.0002123669,0.001907626,0.0003716104,0.00008425521,0.002682247,0.007226066,0.000008377361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001635166,"about_ca_system_score_gemma":0.00167991,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02338832,"about_ca_topic_score_gemma":0.01652283,"domain_scores_codex":[0.9920827,0.002308762,0.0009157926,0.001146819,0.001898101,0.001647792],"domain_scores_gemma":[0.9962509,0.001944986,0.0001215789,0.001241463,0.0003110101,0.0001301112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004917765,0.0007269809,0.4720714,0.001461247,0.0001298336,0.001535579,0.002154076,0.00001788045,0.5130638,0.00006666116,0.0007484827,0.003106292],"study_design_scores_gemma":[0.0152109,0.001536798,0.6625505,0.002495744,0.00004300414,0.00006822705,0.01893986,0.00245192,0.2767268,0.004381687,0.0144742,0.001120295],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845805,0.008642275,0.000001172307,0.001397984,0.0001038036,0.003258516,0.00006258958,0.00005246251,0.001900694],"genre_scores_gemma":[0.9972033,0.0006880148,0.00003150444,0.0006049686,0.0001500499,0.001078175,0.00004353693,0.00007579627,0.0001246338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2363369,"threshold_uncertainty_score":0.999882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06118936530658179,"score_gpt":0.4105562258990918,"score_spread":0.34936686059251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}