{"id":"W4312102451","doi":"10.21203/rs.3.rs-2397012/v1","title":"The Peptidyl-Prolyl cis-trans Isomerase, Pin1, Associates with Protein Kinase C θ (PKCθ) via a Critical Phospho-Thr-Pro Motif in the V3 Regulatory Domain","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Ben-Gurion University of the Negev; Kreitman School of Advanced Graduate Studies, Ben-Gurion University of the Negev; Israel Science Foundation; United States-Israel Binational Science Foundation; Israel Cancer Research Fund","keywords":"PIN1; Protein kinase C; Phosphorylation; Prolyl isomerase; Biology; Cell biology; Kinase; WW domain; Isomerase; Mutant; Peptidylprolyl isomerase; Biochemistry; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147874,0.0005841951,0.0001961486,0.0001909783,0.0002015148,0.0002755795,0.0003030621,0.0002906207,0.001756221],"category_scores_gemma":[0.0001237588,0.0002478543,0.0004001549,0.000142186,0.0002159461,0.0001859968,0.0003138662,0.0005162282,0.0007216948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003692273,"about_ca_system_score_gemma":0.000157809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003547216,"about_ca_topic_score_gemma":0.0003581383,"domain_scores_codex":[0.9998579,0.00001895959,0.000008713078,0.00004422065,0.0000318799,0.00003833206],"domain_scores_gemma":[0.9998755,0.0000118512,0.00006181822,0.00000712191,0.000005698723,0.00003789703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000187491,0.00002245243,0.0004504931,0.00005058292,0.000008143886,0.0001209213,0.000007037804,0.00008133824,0.9982712,0.00009618561,0.00002964264,0.0006744511],"study_design_scores_gemma":[0.00002464041,0.0002121548,0.01562861,0.00001141563,0.00001942387,0.001054771,0.0000339302,0.002062092,0.9784896,0.00009723628,0.00235814,0.000007907829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947437,0.001223236,0.002815102,0.00007994811,0.00002647846,0.000023357,0.0001589624,0.00005124423,0.0008779364],"genre_scores_gemma":[0.9952773,0.0005128178,0.001965042,0.00005640277,0.00001109242,0.00002364513,0.0003854852,0.00001208108,0.001756176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756221,"threshold_uncertainty_score":0.00587517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904081576316148,"score_gpt":0.3506441904036954,"score_spread":0.321603374640534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}