{"id":"W4312102451","doi":"10.21203/rs.3.rs-2397012/v1","title":"The Peptidyl-Prolyl cis-trans Isomerase, Pin1, Associates with Protein Kinase C θ (PKCθ) via a Critical Phospho-Thr-Pro Motif in the V3 Regulatory Domain","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Ben-Gurion University of the Negev; Kreitman School of Advanced Graduate Studies, Ben-Gurion University of the Negev; Israel Science Foundation; United States-Israel Binational Science Foundation; Israel Cancer Research Fund","keywords":"PIN1; Protein kinase C; Phosphorylation; Prolyl isomerase; Biology; Cell biology; Kinase; WW domain; Isomerase; Mutant; Peptidylprolyl isomerase; Biochemistry; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00626874,0.0005451659,0.0004224386,0.000156496,0.001137696,0.0003751499,0.002291426,0.0005667462,0.0001670455],"category_scores_gemma":[0.001867953,0.0003684701,0.0003600244,0.0005821452,0.001212116,0.000008619192,0.001571172,0.003086246,0.00001728784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003382422,"about_ca_system_score_gemma":0.001431489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003141149,"about_ca_topic_score_gemma":0.0004187586,"domain_scores_codex":[0.9909771,0.003228432,0.0005611719,0.001398033,0.002425677,0.00140957],"domain_scores_gemma":[0.9958499,0.0006571023,0.0001489525,0.002455265,0.0005958963,0.0002928948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01812217,0.009249887,0.06788753,0.008172936,0.00242596,0.005371821,0.01177235,0.00371552,0.8062667,0.01022177,0.04423621,0.0125572],"study_design_scores_gemma":[0.01281839,0.01389962,0.08053529,0.006505842,0.0004492345,0.0001839499,0.03543247,0.001367753,0.582991,0.09631509,0.1619901,0.007511274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978295,0.01082902,0.0003032904,0.005095688,0.000159395,0.004112867,0.0004963452,0.00007052998,0.0006378588],"genre_scores_gemma":[0.9926508,0.0002349401,0.0003005966,0.0001903733,0.000396428,0.00515914,0.0004377936,0.0001639964,0.0004659005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2232756,"threshold_uncertainty_score":0.9998767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904081576316148,"score_gpt":0.3506441904036954,"score_spread":0.321603374640534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}