{"id":"W4312113941","doi":"10.1161/circgen.121.003641","title":"Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†","year":2022,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Division of Research Capacity Development; Medical Research Council; National Research Foundation; British Heart Foundation; Wellcome Trust; South African Medical Research Council; Canadian Institutes of Health Research; American Heart Association; Economic and Social Research Council; Sanofi; Department for International Development; Bristol-Myers Squibb; McMaster University; Amgen; Cisco Systems","keywords":"Medicine; Genome-wide association study; Proband; Heart disease; Case-control study; Disease; Internal medicine; Genetics; Genotype; Biology; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02776685,0.002921677,0.001450118,0.002098702,0.00327072,0.002115161,0.003721625,0.002450575,0.01436337],"category_scores_gemma":[0.02363314,0.002122545,0.0009934665,0.00229815,0.002411886,0.002053691,0.001920422,0.002874915,0.005764549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001683354,"about_ca_system_score_gemma":0.00585516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00351174,"about_ca_topic_score_gemma":0.006342088,"domain_scores_codex":[0.9834822,0.01080694,0.00139267,0.002279232,0.001389852,0.0006489632],"domain_scores_gemma":[0.9941654,0.001276546,0.0009270532,0.001264551,0.001341437,0.001024937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1027321,0.01626677,0.4056672,0.01171778,0.003338915,0.004759694,0.008264927,0.003399693,0.008930864,0.07179557,0.219241,0.1438853],"study_design_scores_gemma":[0.05981012,0.02455495,0.2665517,0.008873759,0.003565242,0.004981872,0.004582543,0.00942348,0.004497104,0.05361865,0.558831,0.0007095265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.1138441,0.008473406,0.06055465,0.01537796,0.00484327,0.7122909,0.0585476,0.0003614313,0.02570668],"genre_scores_gemma":[0.1196584,0.001513961,0.0420713,0.008005468,0.001043092,0.811836,0.01103159,0.00009553893,0.004744548],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02776685,"threshold_uncertainty_score":0.1468469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105764147333228,"score_gpt":0.2762619276837972,"score_spread":0.2452042862104649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}