{"id":"W4312113941","doi":"10.1161/circgen.121.003641","title":"Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†","year":2022,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Division of Research Capacity Development; Medical Research Council; National Research Foundation; British Heart Foundation; Wellcome Trust; South African Medical Research Council; Canadian Institutes of Health Research; American Heart Association; Economic and Social Research Council; Sanofi; Department for International Development; Bristol-Myers Squibb; McMaster University; Amgen; Cisco Systems","keywords":"Medicine; Genome-wide association study; Proband; Heart disease; Case-control study; Disease; Internal medicine; Genetics; Genotype; Biology; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001218687,0.00009024293,0.0002675969,0.00003634813,0.0003565869,0.000005108305,0.00006534971,0.00001605694,0.0002162946],"category_scores_gemma":[0.0002559795,0.00004201072,0.00004511741,0.0002022288,0.0002498948,0.00001289549,0.00009047992,0.0001005699,6.49206e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002572228,"about_ca_system_score_gemma":0.0000627271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002062524,"about_ca_topic_score_gemma":7.572323e-7,"domain_scores_codex":[0.9986067,0.0004535653,0.0004406477,0.0001394541,0.0002863693,0.00007326202],"domain_scores_gemma":[0.9983633,0.000950193,0.0002189853,0.000316405,0.00009966937,0.0000514378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008129714,0.0002276359,0.9614155,0.00005131069,0.0002013719,0.000001126205,0.001880394,0.009115187,0.0005908637,0.0003642822,0.001012443,0.02432694],"study_design_scores_gemma":[0.002836924,0.0001999007,0.9698657,0.00005647704,0.0004094201,0.00001978934,0.0002840761,0.02426569,0.000004654473,0.00122029,0.000800825,0.0000362617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849609,0.003127437,0.006719568,0.002393619,0.0001995952,0.002554719,0.00001059073,0.000005205259,0.00002832858],"genre_scores_gemma":[0.998991,0.0001939925,0.0001391793,0.0003384939,0.00009937779,0.0001113211,0.00002152847,0.000008374656,0.00009678191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02429068,"threshold_uncertainty_score":0.2742614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105764147333228,"score_gpt":0.2762619276837972,"score_spread":0.2452042862104649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}