{"id":"W4312114220","doi":"10.1002/1878-0261.13364","title":"<scp>JAK–STAT</scp> signalling shapes the <scp>NF‐κB</scp> response in <scp>CLL</scp> towards venetoclax sensitivity or resistance via <scp>Bcl‐XL</scp>","year":2022,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Hematology Association","keywords":"Venetoclax; stat; Signalling; Cell biology; Biology; Signal transduction; Immunology; Leukemia; STAT3; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197306,0.0001896062,0.000187942,0.0002281814,0.0002098541,0.0006401355,0.00009025758,0.0002638657,0.003966141],"category_scores_gemma":[0.0001118879,0.0001556988,0.0002108889,0.0001655623,0.0002878809,0.0002280342,0.0001849182,0.0007970872,0.0008103819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003829435,"about_ca_system_score_gemma":0.0002401022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812581,"about_ca_topic_score_gemma":0.001035033,"domain_scores_codex":[0.9998176,0.00002769496,0.00001026318,0.00003190912,0.00004006765,0.00007259404],"domain_scores_gemma":[0.999905,0.00002287551,0.00001870488,0.00000605556,0.000007396988,0.00003992643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000377882,0.00002455042,0.0005120971,0.0000403595,0.000002755878,0.00004533899,0.00002336956,0.00007402442,0.9980332,0.00009161383,0.00006676939,0.0007080119],"study_design_scores_gemma":[0.00007553532,0.0005439047,0.0393147,0.0000203397,0.00002766776,0.0006523241,0.0002193689,0.002868136,0.9507246,0.0002372622,0.00530399,0.00001233543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966275,0.0007693162,0.0006017813,0.0001059937,0.00001776598,0.00001411422,0.0004850531,0.00004405702,0.001334287],"genre_scores_gemma":[0.9970758,0.0003915076,0.0004219529,0.00005648292,0.00001053566,0.00002042563,0.0005386288,0.00001090398,0.001473642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003966141,"threshold_uncertainty_score":0.01326811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421677806317855,"score_gpt":0.3122897424201715,"score_spread":0.2880729643569929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}