{"id":"W4312114220","doi":"10.1002/1878-0261.13364","title":"<scp>JAK–STAT</scp> signalling shapes the <scp>NF‐κB</scp> response in <scp>CLL</scp> towards venetoclax sensitivity or resistance via <scp>Bcl‐XL</scp>","year":2022,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Hematology Association","keywords":"Venetoclax; stat; Signalling; Cell biology; Biology; Signal transduction; Immunology; Leukemia; STAT3; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.01089701,0.001502799,0.002639295,0.001361276,0.001200874,0.0002236336,0.001903141,0.001217282,0.0001218697],"category_scores_gemma":[0.03137685,0.001342377,0.0008963015,0.003628353,0.001429207,0.0003054517,0.002425917,0.00424881,0.0004155497],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03829901,"about_ca_system_score_gemma":0.03196723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00157514,"about_ca_topic_score_gemma":0.001796952,"domain_scores_codex":[0.9789003,0.008227195,0.002184005,0.002896634,0.003623173,0.004168752],"domain_scores_gemma":[0.9671398,0.02740999,0.001001561,0.002439223,0.0008001745,0.001209182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002163569,0.002761376,0.0009268608,0.00132555,0.002071924,0.1252836,0.02684667,0.03459489,0.6552966,0.0009882414,0.1419329,0.005807713],"study_design_scores_gemma":[0.02863427,0.006578972,0.004421154,0.000458055,0.0007656388,0.005714937,0.01475938,0.04583839,0.09554201,0.001502394,0.7955351,0.0002496665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699991,0.007147347,0.003494851,0.001565728,0.0009212956,0.003877522,0.0002321749,0.0004883382,0.0122736],"genre_scores_gemma":[0.9641281,0.0006396987,0.002043951,0.005985401,0.0007273504,0.001457614,0.0002478825,0.0005204286,0.02424962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6536022,"threshold_uncertainty_score":0.9997721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421677806317855,"score_gpt":0.3122897424201715,"score_spread":0.2880729643569929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}