{"id":"W4312115002","doi":"10.1182/blood.2022017147","title":"Novel insights into Hodgkin lymphoma biology by single-cell analysis","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Tumor microenvironment; Biology; Computational biology; Immunotherapy; Immune system; Single-cell analysis; Systems biology; Lymphoma; Cell; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009079566,0.000181951,0.0002219419,0.000113204,0.0002216775,0.00002098268,0.0003268973,0.000126993,0.00006771829],"category_scores_gemma":[0.00001446245,0.0001875701,0.0002087614,0.0003838206,0.00006785747,0.000002344458,0.0001700646,0.00008065176,0.000005085643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002166879,"about_ca_system_score_gemma":0.0000543559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003096647,"about_ca_topic_score_gemma":0.0001546948,"domain_scores_codex":[0.9988344,0.00008386965,0.0002294966,0.0004804104,0.0001192758,0.0002525139],"domain_scores_gemma":[0.9994035,0.00001385736,0.00008678615,0.0003723881,0.00003887762,0.00008458913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004270039,0.001833313,0.005963479,0.000006279326,0.0003798394,0.000002985781,0.0001112952,0.00006821768,0.9903131,0.00002760186,0.0004050938,0.0008461584],"study_design_scores_gemma":[0.002821858,0.0008106921,0.0003741729,9.753389e-7,0.0004663048,0.00001024126,0.00008236658,0.0001187959,0.8862965,0.00006296188,0.1086076,0.0003475572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888382,0.002544576,0.006895899,0.00005177922,0.0001825941,0.00009685581,0.00007219281,0.00002417291,0.001293717],"genre_scores_gemma":[0.996742,0.00006208227,0.001016687,0.0004706506,0.00011479,0.0000336952,0.0009356892,0.00002757684,0.0005967941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1082025,"threshold_uncertainty_score":0.7648888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009523246311929153,"score_gpt":0.2057959706925294,"score_spread":0.1962727243806002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}