{"id":"W4312115155","doi":"10.1007/s10557-022-07413-0","title":"Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials","year":2022,"lang":"en","type":"article","venue":"Cardiovascular Drugs and Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novartis Pharma","keywords":"Medicine; Placebo; Adverse effect; Post-hoc analysis; Internal medicine; Confidence interval; Randomized controlled trial; Dosing; Clinical trial; Lipid profile; Cholesterol; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01100173,0.002052312,0.006171261,0.0007375223,0.0002539929,0.001707502,0.0007164945,0.0009531443,0.003149149],"category_scores_gemma":[0.009269038,0.0006274445,0.0109598,0.0009009602,0.0005611895,0.001048236,0.0005704165,0.001794619,0.0003080871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006412046,"about_ca_system_score_gemma":0.001025491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005458057,"about_ca_topic_score_gemma":0.001573015,"domain_scores_codex":[0.9938686,0.004335193,0.0006495944,0.0005906842,0.0003251747,0.000230632],"domain_scores_gemma":[0.9932854,0.003564559,0.0018726,0.0005581076,0.0004091739,0.0003100385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8564048,0.0006707116,0.004075906,0.004745175,0.1173803,0.00006471514,0.00004248771,0.000822032,0.001610824,0.00006947193,0.000967752,0.01314585],"study_design_scores_gemma":[0.6840704,0.06278351,0.03429405,0.0006289108,0.2114148,0.0001793383,0.0001013674,0.002066866,0.001542101,0.0004348927,0.002377494,0.0001061928],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.894932,0.08978166,0.003175035,0.0007557807,0.001134026,0.003294992,0.003916968,0.0002857698,0.002723624],"genre_scores_gemma":[0.9800238,0.01162604,0.002163609,0.0006886442,0.0006137906,0.001734378,0.002038243,0.00005912815,0.001052354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01100173,"threshold_uncertainty_score":0.05818343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00802894109880252,"score_gpt":0.2499718252205237,"score_spread":0.2419428841217212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}