{"id":"W4312115155","doi":"10.1007/s10557-022-07413-0","title":"Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials","year":2022,"lang":"en","type":"article","venue":"Cardiovascular Drugs and Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novartis Pharma","keywords":"Medicine; Placebo; Adverse effect; Post-hoc analysis; Internal medicine; Confidence interval; Randomized controlled trial; Dosing; Clinical trial; Lipid profile; Cholesterol; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01158953,0.0003945022,0.006713038,0.000514763,0.000293551,0.00002986966,0.0001484498,0.00009340155,0.00008483943],"category_scores_gemma":[0.0005860933,0.0002162428,0.004108781,0.001130789,0.0003457447,0.00008005431,0.0001430151,0.0002511602,1.051186e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006581159,"about_ca_system_score_gemma":0.0002626574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005494213,"about_ca_topic_score_gemma":0.000008505768,"domain_scores_codex":[0.992727,0.003458247,0.001331873,0.0006101339,0.001567341,0.0003053553],"domain_scores_gemma":[0.9970051,0.0006429639,0.0005453933,0.001211185,0.0003370387,0.0002582941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6754255,0.001289159,0.019108,0.0002826594,0.1189055,0.00002763261,0.001757249,0.0007507978,0.00007429306,0.0002959373,0.000008782623,0.1820746],"study_design_scores_gemma":[0.862152,0.0009108144,0.1016273,0.0001571002,0.02948214,0.000008906446,0.0003846027,0.0003022598,0.00004570049,0.00003107152,0.004581262,0.0003168398],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8545029,0.1392793,0.0001056729,0.0002136439,0.00009304027,0.005612577,0.0001562761,0.00001393782,0.00002269319],"genre_scores_gemma":[0.9841363,0.01510508,0.00004061491,0.0001496147,0.00008039745,0.0002774963,0.0001404538,0.00004130843,0.00002871139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1867266,"threshold_uncertainty_score":0.8818127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00802894109880252,"score_gpt":0.2499718252205237,"score_spread":0.2419428841217212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}