{"id":"W4312124760","doi":"10.53350/pjmhs221610891","title":"Chemotherapy for Pancreatic Cancer can be Optimized with the Use of Drug Resistance Testing Using Tissue Organoids","year":2022,"lang":"en","type":"article","venue":"","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbott (Canada)","funders":"","keywords":"Medicine; Pancreatic cancer; Internal medicine; FOLFIRINOX; Regimen; Chemotherapy; Neoadjuvant therapy; Oncology; Cancer; Drug resistance; Surgery; Irinotecan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006180062,0.000230305,0.0003431411,0.0005063118,0.0001136885,0.0003360883,0.0001412868,0.0001667237,0.001155437],"category_scores_gemma":[0.0005856117,0.00009018661,0.0002263828,0.0003248791,0.0002420126,0.0003834314,0.0004355637,0.000267465,0.0004464115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008760402,"about_ca_system_score_gemma":0.0001173046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009485563,"about_ca_topic_score_gemma":0.0001610492,"domain_scores_codex":[0.9996868,0.0001245564,0.00002775074,0.00005145583,0.0000777071,0.00003166656],"domain_scores_gemma":[0.999691,0.0001007378,0.00007986505,0.00006385014,0.0000394386,0.00002511372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001590395,0.0003365383,0.06532979,0.0004531119,0.00004348109,0.001342609,0.0002350868,0.0009618032,0.7689064,0.0002067807,0.0004235129,0.1601706],"study_design_scores_gemma":[0.0001720168,0.01847946,0.2200599,0.0002457037,0.0002562985,0.01788087,0.0009966817,0.004509964,0.7017618,0.0005123083,0.03506539,0.00005954888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783905,0.006649054,0.01106877,0.0002241987,0.00006023861,0.00009936622,0.0001485847,0.000196702,0.003162727],"genre_scores_gemma":[0.9901579,0.002632779,0.006202084,0.00006160859,0.0000225559,0.00005247326,0.0002112761,0.00001385513,0.0006454149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155437,"threshold_uncertainty_score":0.003865302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014173089628018,"score_gpt":0.3655998363666061,"score_spread":0.2641825274038043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}