{"id":"W4312126068","doi":"10.3390/ijms232415742","title":"The J Domain of Sacsin Disrupts Intermediate Filament Assembly","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Muscular Dystrophy Canada; McGill University","keywords":"Intermediate filament; Vimentin; Cell biology; Neurofilament; Regulator; Biology; Protein filament; Intermediate Filament Protein; Protein domain; Chemistry; Gene; Cytoskeleton; Cell; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365796,0.0003541304,0.0001724454,0.0002610965,0.0001580249,0.0002104207,0.0002423315,0.0004406634,0.001321744],"category_scores_gemma":[0.0001470441,0.0002120416,0.0002753224,0.0001378407,0.0002868806,0.0001331217,0.0002004298,0.0004325076,0.0003216134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111523,"about_ca_system_score_gemma":0.0001831649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007226,"about_ca_topic_score_gemma":0.001246258,"domain_scores_codex":[0.9998564,0.00002842736,0.00002814549,0.000026334,0.0000300822,0.00003074675],"domain_scores_gemma":[0.9997649,0.00006019559,0.00006652365,0.00002338743,0.00001354713,0.00007145268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000720317,0.00002560583,0.0001058706,0.00002107383,0.000006239163,0.0001193653,0.0000123134,0.00004792397,0.9991882,0.00008830073,0.00001879525,0.0002942763],"study_design_scores_gemma":[0.00003420092,0.0005013118,0.004922354,0.0000110475,0.00002276549,0.0008847947,0.00004041502,0.001997838,0.989158,0.00006112627,0.002356868,0.000009268289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997655,0.0003370749,0.001218951,0.00004226069,0.00003450362,0.00001241255,0.0001276173,0.00005258515,0.0005195649],"genre_scores_gemma":[0.9979908,0.0001291701,0.000622585,0.00002519204,0.000005722259,0.000008084745,0.0001674012,0.00001714637,0.001033869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321744,"threshold_uncertainty_score":0.004421651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337580224977549,"score_gpt":0.3268683204686679,"score_spread":0.3134925182188925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}