{"id":"W4312128716","doi":"10.3233/jad-220535","title":"Obesity-Associated Neurodegeneration Pattern Mimics Alzheimer’s Disease in an Observational Cohort Study","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Eli Lilly and Company; U.S. Department of Defense; Compute Canada; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Obesity; Medicine; Cognitive decline; Internal medicine; Disease; Dyslipidemia; Cohort; Neurodegeneration; Diabetes mellitus; Dementia; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001234509,0.0003359679,0.0004832102,0.0008421519,0.0007728586,0.0008664961,0.0005553807,0.0005310684,0.001209896],"category_scores_gemma":[0.002308446,0.0004718299,0.0007212648,0.001427796,0.0003098368,0.0004708015,0.0006134622,0.0006903869,0.0002661785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000334125,"about_ca_system_score_gemma":0.0004635126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008814183,"about_ca_topic_score_gemma":0.01248631,"domain_scores_codex":[0.9991704,0.0002370235,0.00009997249,0.0002671244,0.0001288779,0.00009660021],"domain_scores_gemma":[0.998567,0.0001742859,0.0005303447,0.0002968792,0.0001727562,0.0002587199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000132002,0.00003640481,0.999029,0.000007799876,0.0001361151,0.00008798105,0.00005297126,0.00001275741,0.0001563207,0.00001717621,0.0000738025,0.0002575852],"study_design_scores_gemma":[0.00001353416,0.00006241025,0.999163,0.000005123772,0.0000746083,0.0002816367,0.0001185722,0.0001232284,0.00002165324,0.00002701703,0.0001052668,0.000003992933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988242,0.0001755229,0.0001360576,0.00002502617,0.000007247113,0.00002088026,0.000542474,0.000002678312,0.0002658982],"genre_scores_gemma":[0.9991117,0.00009742123,0.0001125633,0.00002548314,0.000007252214,0.00001864006,0.0005529231,0.00000253747,0.00007145506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008814183,"threshold_uncertainty_score":0.01752579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08101578389368565,"score_gpt":0.3539677836067589,"score_spread":0.2729519997130733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}