{"id":"W4312128716","doi":"10.3233/jad-220535","title":"Obesity-Associated Neurodegeneration Pattern Mimics Alzheimer’s Disease in an Observational Cohort Study","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Eli Lilly and Company; U.S. Department of Defense; Compute Canada; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Obesity; Medicine; Cognitive decline; Internal medicine; Disease; Dyslipidemia; Cohort; Neurodegeneration; Diabetes mellitus; Dementia; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001197428,0.0002001298,0.0003645894,0.0003892427,0.0002414799,0.00007288583,0.0002241604,0.00002349819,0.0008150796],"category_scores_gemma":[0.0001732472,0.0001922822,0.000205056,0.0004338096,0.00004098212,0.0004444012,0.0001411823,0.0005246743,0.000008082596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416838,"about_ca_system_score_gemma":0.0008773716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004208348,"about_ca_topic_score_gemma":0.00002264908,"domain_scores_codex":[0.996095,0.0007444856,0.0007207268,0.0003206034,0.001789237,0.0003299167],"domain_scores_gemma":[0.9978933,0.00005401739,0.0003461011,0.0002748512,0.0005688401,0.0008628677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001278079,0.0106207,0.9824138,0.00000693653,0.0007035204,0.00199467,0.0001620098,0.0005664666,0.0001069498,0.000006719596,0.0007826943,0.001357474],"study_design_scores_gemma":[0.003537652,0.001459796,0.9873409,0.0000239071,0.003173973,0.00001021321,0.0002624473,0.003820813,0.00003642997,0.00007101247,0.00009077591,0.0001720928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954395,0.001297344,0.00003036798,0.001654295,0.0002709756,0.001176958,0.00008076584,0.00001797259,0.00003183633],"genre_scores_gemma":[0.9978145,0.00002767054,0.00002062047,0.001431413,0.0001974275,0.0001092667,0.0003193162,0.00003435364,0.00004537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009160906,"threshold_uncertainty_score":0.892455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08101578389368565,"score_gpt":0.3539677836067589,"score_spread":0.2729519997130733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}