{"id":"W4312128886","doi":"10.1186/s13195-022-01142-0","title":"CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals","year":2022,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Canadian Institutes of Health Research; Göteborgs Universitet","keywords":"Neurology; Geriatric psychiatry; Cognition; Psychology; Neocortex; Neuroscience; Medicine; Effects of sleep deprivation on cognitive performance; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002995312,0.0003852835,0.0006388313,0.00110056,0.0008018978,0.0002185174,0.0002485894,0.0001089425,0.001331766],"category_scores_gemma":[0.0002738473,0.0003559363,0.00008337069,0.001534765,0.0006756319,0.0003725051,0.0007144077,0.001494867,0.00008886605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001237027,"about_ca_system_score_gemma":0.0004922328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674923,"about_ca_topic_score_gemma":0.00002726056,"domain_scores_codex":[0.9935282,0.001344055,0.0005437736,0.00100093,0.002120006,0.001463058],"domain_scores_gemma":[0.9972491,0.0009312734,0.00007713363,0.0003225613,0.0006925501,0.0007273509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007977794,0.001706401,0.6622265,0.00007820464,0.001463199,0.0004106004,0.00780876,0.000002482039,0.01933243,0.00005154743,0.006758974,0.2921831],"study_design_scores_gemma":[0.01068214,0.006458865,0.9595492,0.0001917873,0.0001214588,0.0001791494,0.003537155,0.0004985534,0.01311355,0.0001869711,0.005039894,0.000441287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840858,0.003723145,0.00002736916,0.005641465,0.00005340717,0.004457437,0.0000839343,0.00005629321,0.001871152],"genre_scores_gemma":[0.9930316,0.001013658,0.0001690479,0.002906477,0.000151472,0.002025981,0.0001464415,0.00007208815,0.000483205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2973227,"threshold_uncertainty_score":0.9998893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1020957834667428,"score_gpt":0.4035197826239539,"score_spread":0.3014239991572111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}