{"id":"W4312129148","doi":"10.1186/s41181-022-00186-9","title":"Formulation of a kit under Good Manufacturing Practices (GMP) for preparing [111In]In-BnDTPA-trastuzumab-NLS injection: a theranostic agent for imaging and Meitner-Auger Electron (MAE) radioimmunotherapy of HER2-positive breast cancer","year":2022,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Radioimmunotherapy; Trastuzumab; Medical physics; Nuclear medicine; Medicine; Breast cancer; Internal medicine; Cancer; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00138257,0.001388975,0.0007218182,0.001082756,0.0003559573,0.0004508029,0.0008152095,0.0008710361,0.006461393],"category_scores_gemma":[0.001165925,0.0006375624,0.000600082,0.0005347196,0.0002980488,0.0003643439,0.0004408014,0.0007483716,0.006828662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573653,"about_ca_system_score_gemma":0.0004591545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002577827,"about_ca_topic_score_gemma":0.0005756801,"domain_scores_codex":[0.9988143,0.000272986,0.0001355464,0.0001721847,0.0005098941,0.00009512717],"domain_scores_gemma":[0.9993762,0.0001159456,0.0001642019,0.0001083656,0.0001729765,0.0000622916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478045,0.0001539924,0.0003146284,0.0003569418,0.00002841245,0.0001616625,0.0000498345,0.0007186739,0.9834268,0.0002829451,0.0009599326,0.01339839],"study_design_scores_gemma":[0.0000966092,0.001646544,0.00191753,0.0000652389,0.0001093391,0.0009925555,0.00002650689,0.002823824,0.9491246,0.000174581,0.04297921,0.00004356557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2962984,0.004150731,0.6570407,0.0005798941,0.0006310745,0.01202861,0.006942435,0.00699374,0.01533446],"genre_scores_gemma":[0.289914,0.002981654,0.6613058,0.0003287327,0.0001878563,0.01198662,0.01183323,0.0009253587,0.0205366],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006461393,"threshold_uncertainty_score":0.02161551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564949017135576,"score_gpt":0.3415095669100575,"score_spread":0.3258600767387017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}