{"id":"W4312129148","doi":"10.1186/s41181-022-00186-9","title":"Formulation of a kit under Good Manufacturing Practices (GMP) for preparing [111In]In-BnDTPA-trastuzumab-NLS injection: a theranostic agent for imaging and Meitner-Auger Electron (MAE) radioimmunotherapy of HER2-positive breast cancer","year":2022,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Radioimmunotherapy; Trastuzumab; Medical physics; Nuclear medicine; Medicine; Breast cancer; Internal medicine; Cancer; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500107,0.0002160572,0.0003673405,0.00004425502,0.0002099767,0.00001928112,0.00008744463,0.00004429904,0.0001080241],"category_scores_gemma":[0.00002067928,0.0002237569,0.0001141295,0.0001276009,0.00008440793,0.0001481737,0.00003343331,0.0002734924,4.62193e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303015,"about_ca_system_score_gemma":0.000116152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006608217,"about_ca_topic_score_gemma":0.000001045829,"domain_scores_codex":[0.998682,0.00002549784,0.0004230853,0.000396331,0.0001906857,0.0002823491],"domain_scores_gemma":[0.9989734,0.0002859267,0.0004230375,0.0001647027,0.00006688613,0.00008601603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002798066,0.0003567692,0.002392238,0.001467256,0.0002985575,0.000002806248,0.000529283,0.0008138023,0.9851087,0.00005320756,0.00006042386,0.006118892],"study_design_scores_gemma":[0.005642001,0.0001034028,0.004834292,0.0001494465,0.0003728621,0.000486011,0.0005125537,0.006286867,0.9789504,0.0002347422,0.002193979,0.0002334414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918993,0.00495374,0.0006334989,0.0009714295,0.00004337755,0.0009695583,0.000186538,0.00002554467,0.0003170745],"genre_scores_gemma":[0.9978776,0.0005661366,0.000247479,0.000166986,0.000163483,0.0006155825,0.00006559054,0.00003474853,0.0002624145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006158296,"threshold_uncertainty_score":0.912454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564949017135576,"score_gpt":0.3415095669100575,"score_spread":0.3258600767387017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}