{"id":"W4312129369","doi":"10.1186/s13148-022-01400-w","title":"Transient Polycomb activity represses developmental genes in growing oocytes","year":2022,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Health and Medical Research Council; State Government of Victoria; Hudson Institute of Medical Research; Monash University","keywords":"PRC2; Biology; Genomic imprinting; Epigenetics; Genetics; Germline; Oocyte; Histone; Gene; Polycomb-group proteins; Imprinting (psychology); Phenotype; Cell biology; Histone H3; Embryo; DNA methylation; Gene expression; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008585775,0.0001870317,0.0001443247,0.0001731866,0.0001109546,0.0002577578,0.0002008182,0.0001480516,0.0009769631],"category_scores_gemma":[0.0001245612,0.0001291143,0.0002098795,0.0001042088,0.0002004732,0.0001628882,0.0001993572,0.0003278539,0.0003209876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168423,"about_ca_system_score_gemma":0.0001612288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006138725,"about_ca_topic_score_gemma":0.001375628,"domain_scores_codex":[0.9998978,0.000006710367,0.00001057941,0.00003689506,0.00002850474,0.00001950573],"domain_scores_gemma":[0.999878,0.00002102304,0.00004079633,0.00001731846,0.00001682229,0.00002597356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002894571,0.000002236588,0.0002958313,0.00001235893,0.000001698212,0.0000232187,0.000006416336,0.000007816723,0.9992259,0.0000455677,0.000008353114,0.0003417076],"study_design_scores_gemma":[0.000008292079,0.00008583275,0.01261004,0.0000038762,0.00001169561,0.0003430348,0.00002008309,0.0003364981,0.9844794,0.00004691935,0.002052437,0.000001889074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906321,0.002289364,0.004793504,0.0000598352,0.00002545859,0.00002346067,0.0005813237,0.00008611241,0.001508693],"genre_scores_gemma":[0.9921187,0.0008002433,0.002564781,0.00003919512,0.00001358197,0.00002847568,0.0009281582,0.00003932924,0.003467469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009769631,"threshold_uncertainty_score":0.003268242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09359001747846676,"score_gpt":0.3776491247881408,"score_spread":0.2840591073096741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}