{"id":"W4312129642","doi":"10.1186/s13071-022-05571-6","title":"Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance","year":2022,"lang":"en","type":"article","venue":"Parasites & Vectors","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Georgia","keywords":"Dirofilaria immitis; Biology; Single-nucleotide polymorphism; Microfilaria; SNP; Molecular biology; Gene; Genetics; Genotype; Immunology; Helminths; Filariasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101139,0.0001730457,0.0003943875,0.000172016,0.0001370713,0.000008046175,0.00007543668,0.00004079374,0.000625225],"category_scores_gemma":[0.0001618362,0.0001584261,0.00006752214,0.0003428543,0.0003581437,0.00005748634,0.00009165656,0.0001034074,0.000005369289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198252,"about_ca_system_score_gemma":0.0001648189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004996427,"about_ca_topic_score_gemma":0.00003074509,"domain_scores_codex":[0.9983748,0.000218401,0.0003243109,0.0003172956,0.0005038546,0.0002613692],"domain_scores_gemma":[0.9990792,0.0001980338,0.0001900641,0.0002341585,0.0000990571,0.0001995288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002655413,0.0008892828,0.7984364,0.0003806636,0.0003219753,0.0005587557,0.001070247,0.000140356,0.1925607,0.0005407955,0.0004684898,0.001976884],"study_design_scores_gemma":[0.003144633,0.0007822486,0.6964723,0.0002957961,0.0002638867,0.00006647281,0.0005280473,0.0002811866,0.296607,0.0003768895,0.0009626093,0.0002188957],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989818,0.006058334,0.00149514,0.00008377092,0.00004196327,0.0009081409,0.0003857512,0.0000228489,0.001186043],"genre_scores_gemma":[0.9978678,0.0001235833,0.001025033,0.00003120215,0.0000162057,0.000184114,0.0001395065,0.00001975098,0.0005928447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1040462,"threshold_uncertainty_score":0.6845775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00845472137100211,"score_gpt":0.2858451438443205,"score_spread":0.2773904224733184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}