{"id":"W4312137408","doi":"10.21203/rs.3.rs-2355585/v1","title":"Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ- PBMC-HPV) in HLA-A*02+ patients with HPV16+ Solid Tumors","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Peripheral blood mononuclear cell; Medicine; Pharmacodynamics; Tolerability; CD8; Immune system; Antigen; Immunotherapy; Immunology; Human leukocyte antigen; Internal medicine; Adverse effect; Pharmacokinetics; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007796316,0.0005702842,0.0007550267,0.0001402809,0.0002000259,0.0003893313,0.0002559066,0.0005514459,0.0025073],"category_scores_gemma":[0.0004586809,0.0002496011,0.0003875423,0.0001079362,0.0003761467,0.0003045517,0.0001563813,0.001253036,0.0004175643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000323336,"about_ca_system_score_gemma":0.000512505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001480187,"about_ca_topic_score_gemma":0.0003062559,"domain_scores_codex":[0.9997517,0.0001110845,0.0000100653,0.00005446825,0.00003119362,0.0000414999],"domain_scores_gemma":[0.9996824,0.00007644944,0.00008912641,0.00003616648,0.00002481372,0.00009102574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2172171,0.1014133,0.01909229,0.0004859836,0.0003686936,0.0003876475,0.0004678908,0.004829489,0.5192515,0.0005304917,0.00279673,0.133159],"study_design_scores_gemma":[0.03405654,0.9237761,0.009240122,0.00001081776,0.0000885917,0.000259705,0.00004666376,0.001350422,0.02862314,0.0001407161,0.002396199,0.00001101699],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973756,0.0002554226,0.0006017276,0.00006978784,0.00003649471,0.0009915465,0.0002035317,0.00002389935,0.0004419352],"genre_scores_gemma":[0.9946021,0.0001968865,0.001720956,0.0002562778,0.00006291352,0.001311953,0.0004040785,0.00001140349,0.001433343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025073,"threshold_uncertainty_score":0.008387744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08236097604119805,"score_gpt":0.4336529150774708,"score_spread":0.3512919390362728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}