{"id":"W4312139245","doi":"10.1136/ijgc-2022-igcs.525","title":"TP016/#1442 Keynote-C93/GOG-3064/ENGOT-EN15: phase 3, randomized, open-label study of first-line pembrolizumab versus platinum-doublet chemotherapy in mismatch repair deficient advanced or recurrent endometrial carcinoma","year":2022,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Carboplatin; Pembrolizumab; Medicine; Endometrial cancer; Chemotherapy; Internal medicine; Oncology; Paclitaxel; Clinical endpoint; Randomization; Cancer; Randomized controlled trial; Cisplatin; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384142,0.001391428,0.001954375,0.0004561052,0.0004367256,0.001219235,0.001075679,0.001644922,0.01897212],"category_scores_gemma":[0.0008133236,0.0005587912,0.00138646,0.0003232503,0.0008111143,0.001040559,0.0003100259,0.003371541,0.002685929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008734721,"about_ca_system_score_gemma":0.001577268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001992828,"about_ca_topic_score_gemma":0.006150021,"domain_scores_codex":[0.9997348,0.0001262181,0.00001115786,0.00004097936,0.00002518067,0.00006158752],"domain_scores_gemma":[0.9996598,0.00006884182,0.00005833888,0.00002400831,0.00002037561,0.0001685593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8742751,0.02161497,0.0008220996,0.001338321,0.001444312,0.0000847491,0.00009143311,0.001191076,0.01568756,0.0005589527,0.01018889,0.07270261],"study_design_scores_gemma":[0.9169657,0.07689227,0.001427823,0.00004875167,0.0003081845,0.00003567929,0.00002718153,0.0006039864,0.0008943954,0.0001659027,0.00261202,0.00001808559],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469613,0.009608927,0.002336856,0.002863687,0.001528908,0.01342573,0.009403149,0.0007867541,0.01308461],"genre_scores_gemma":[0.9378831,0.006323499,0.00613341,0.005045502,0.0006572763,0.01085041,0.0063286,0.0001895828,0.02658863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01897212,"threshold_uncertainty_score":0.0634681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065201393172353,"score_gpt":0.4183910709286756,"score_spread":0.3118709316114402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}