{"id":"W4312139759","doi":"10.1136/ijgc-2022-igcs.9","title":"O007/#456 Post-hoc analysis of objective response rate by mismatch repair protein dimer loss/mutation status in patients with mismatch repair deficient endometrial cancer treated with dostarlimab","year":2022,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Hamilton Health Sciences; Juravinski Cancer Centre; McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; University of British Columbia","funders":"","keywords":"PMS2; MSH2; MSH6; MLH1; Medicine; Cancer research; Mutation; Oncology; DNA mismatch repair; Internal medicine; Endometrial cancer; Cancer; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002343772,0.0003095247,0.001417385,0.0003024568,0.0001767907,0.0007527992,0.0004640966,0.0003864401,0.005846833],"category_scores_gemma":[0.002887495,0.0001329973,0.001746739,0.0003011212,0.0002748999,0.0007169706,0.0003206928,0.001018363,0.0003978211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934845,"about_ca_system_score_gemma":0.0006485466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007850032,"about_ca_topic_score_gemma":0.001127248,"domain_scores_codex":[0.9984206,0.0007501376,0.00009946284,0.0002177903,0.0001995338,0.0003125199],"domain_scores_gemma":[0.9976282,0.001617528,0.0002248985,0.000138474,0.0001318949,0.0002591026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.567223,0.002565278,0.3400492,0.0005518007,0.007156334,0.0004279061,0.0002500553,0.002525122,0.01487997,0.0002668,0.004576831,0.05952778],"study_design_scores_gemma":[0.009994387,0.07893812,0.8756263,0.00005592069,0.004454351,0.0004085021,0.0006392269,0.01370628,0.008193403,0.0004118168,0.007502811,0.00006881748],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957683,0.0005918875,0.0005387308,0.0001712969,0.0001340551,0.00009928484,0.001046212,0.00002376665,0.001626512],"genre_scores_gemma":[0.9966894,0.00007462722,0.0002874723,0.0001140322,0.00006739327,0.0001335212,0.0006480533,0.00001410856,0.001971336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005846833,"threshold_uncertainty_score":0.01955956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009203471795560211,"score_gpt":0.2771018112873833,"score_spread":0.2678983394918231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}