{"id":"W4312155184","doi":"10.1038/s44161-022-00181-y","title":"Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure","year":2022,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto; University of Ottawa","funders":"CIHR Skin Research Training Centre; Ontario Genomics Institute; Genome Canada; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Senescence; Heart failure; Cardiac fibrosis; Pressure overload; Inflammation; Fibrosis; Protein kinase B; Gene knockdown; Myocyte; DNA damage; Growth factor; Medicine; Internal medicine; Endocrinology; Biology; Cell biology; Signal transduction; Apoptosis; Receptor; DNA; Biochemistry; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001882897,0.0002372607,0.0003432956,0.0002545557,0.0008518355,0.00004953635,0.0007758791,0.0007169834,0.00008642271],"category_scores_gemma":[0.0006102659,0.0002514185,0.0006268789,0.0008496602,0.000141445,0.000008498467,0.001215326,0.003159467,0.00006348926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008958863,"about_ca_system_score_gemma":0.0002750319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005491313,"about_ca_topic_score_gemma":0.00001428721,"domain_scores_codex":[0.9955617,0.001171295,0.0001988781,0.001007429,0.001256697,0.0008040413],"domain_scores_gemma":[0.9981334,0.00003875221,0.00002796909,0.001119517,0.0004282045,0.0002521805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000406138,0.0001186992,0.0009938012,0.00008441896,0.0006120966,0.00003808723,0.0001022811,0.0004365971,0.9729396,0.0002879273,0.02211105,0.001869317],"study_design_scores_gemma":[0.001172136,0.0007960465,0.003468982,0.00002541099,0.00002699633,0.0000596547,0.0005399433,0.00001104761,0.2190698,0.0002131259,0.7740175,0.0005993376],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879269,0.008119712,0.0002444178,0.00157875,0.0003377167,0.001228614,0.00006876441,0.0000419913,0.0004531494],"genre_scores_gemma":[0.9972998,0.00008363472,0.0005010278,0.0006302968,0.0003897378,0.0004483459,0.0001921236,0.00005502115,0.0003999622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7538698,"threshold_uncertainty_score":0.9999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908751571057712,"score_gpt":0.3012895154684083,"score_spread":0.2822019997578311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}