{"id":"W4312155184","doi":"10.1038/s44161-022-00181-y","title":"Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure","year":2022,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto; University of Ottawa","funders":"CIHR Skin Research Training Centre; Ontario Genomics Institute; Genome Canada; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Senescence; Heart failure; Cardiac fibrosis; Pressure overload; Inflammation; Fibrosis; Protein kinase B; Gene knockdown; Myocyte; DNA damage; Growth factor; Medicine; Internal medicine; Endocrinology; Biology; Cell biology; Signal transduction; Apoptosis; Receptor; DNA; Biochemistry; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119492,0.0003220402,0.0001905417,0.0003358768,0.0001884638,0.0004287752,0.0001670201,0.0003234097,0.001359905],"category_scores_gemma":[0.000157684,0.0001290107,0.0002920439,0.0001338108,0.0002916441,0.0001408084,0.0002949203,0.0006549297,0.0003333919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686121,"about_ca_system_score_gemma":0.0002965062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009515088,"about_ca_topic_score_gemma":0.001043351,"domain_scores_codex":[0.9999114,0.00001630658,0.000006056396,0.00001538981,0.00002935517,0.00002149231],"domain_scores_gemma":[0.9998869,0.000008612935,0.00003336382,0.000007179958,0.00002747321,0.00003658297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008759731,0.00008949797,0.007978671,0.0003371529,0.00009129885,0.0005183464,0.00006752924,0.0001535626,0.9607962,0.0007302265,0.001406161,0.02695532],"study_design_scores_gemma":[0.0001766376,0.002104914,0.3484626,0.0002148585,0.0004989126,0.003933512,0.0004976761,0.004073311,0.5794417,0.002670059,0.05785283,0.00007304047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9096557,0.06431904,0.01381536,0.002318448,0.0008564225,0.00005881972,0.0009656862,0.0004434679,0.007566992],"genre_scores_gemma":[0.9760059,0.01749817,0.00223255,0.0005589733,0.0001755355,0.00002507896,0.0005088393,0.00002462879,0.002970249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359905,"threshold_uncertainty_score":0.004549325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908751571057712,"score_gpt":0.3012895154684083,"score_spread":0.2822019997578311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}