{"id":"W4312159863","doi":"10.1101/2022.12.12.519332","title":"High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of <i>HOX/MEIS</i> Activation in Acute Myeloid Leukemia","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health; National Cancer Institute; Rally Foundation; Children's Cancer Research Fund","keywords":"Chromatin; Myeloid leukemia; CRISPR; Epigenetics; Transcription factor; Biology; Hox gene; Cancer research; Leukemia; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567626,0.0002903191,0.0002824474,0.0002164398,0.0001219733,0.0003279899,0.0002436648,0.0002283984,0.001533594],"category_scores_gemma":[0.0001207171,0.0001250717,0.0002086679,0.0001273182,0.0001902378,0.00008286702,0.000278733,0.0003452335,0.0003786238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061867,"about_ca_system_score_gemma":0.0001320026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007661029,"about_ca_topic_score_gemma":0.001736953,"domain_scores_codex":[0.9998311,0.00001771433,0.00001270899,0.0000390372,0.00006914005,0.00003030913],"domain_scores_gemma":[0.9999294,0.00002203214,0.00001796205,0.00001023981,0.000006045114,0.00001424775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003127742,0.00001058132,0.0001803484,0.00001151623,0.000003625375,0.00004417976,0.000005312115,0.000215486,0.998301,0.00009728075,0.00005519206,0.001044219],"study_design_scores_gemma":[0.00000876434,0.00005779348,0.001943705,0.000001722658,0.000007598458,0.000146305,0.00001032784,0.001879181,0.9943739,0.00005557096,0.001511546,0.00000351302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654685,0.0005597833,0.0270059,0.0001780066,0.00002228003,0.00009213415,0.002104039,0.0009338953,0.003635401],"genre_scores_gemma":[0.9858862,0.0002467287,0.009914769,0.00008198826,0.000003937321,0.00003626744,0.0009125176,0.00009794235,0.002819586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533594,"threshold_uncertainty_score":0.00513041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008977770374598239,"score_gpt":0.2128649461522748,"score_spread":0.2038871757776766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}