{"id":"W4312172964","doi":"10.3390/vaccines11010030","title":"Characterization of Systemic and Mucosal Humoral Immune Responses to an Adjuvanted Intranasal SARS-CoV-2 Protein Subunit Vaccine Candidate in Mice","year":2022,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Adjuvant; Nasal administration; Immunogenicity; Antibody; Immune system; Virology; Antigen; Immunology; Neutralizing antibody; Vaccination; Humoral immunity; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006783469,0.0002167845,0.0005472456,0.0008375751,0.0001112563,0.00002688043,0.000230078,0.00006658375,0.00002006952],"category_scores_gemma":[0.0001645242,0.0002030084,0.00004680528,0.001074756,0.00001636705,0.0001796496,0.0001983356,0.0002978403,0.000005303984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255927,"about_ca_system_score_gemma":0.000267946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002402944,"about_ca_topic_score_gemma":0.0006336274,"domain_scores_codex":[0.99794,0.0003435448,0.0005824725,0.0004064146,0.0003612814,0.0003663004],"domain_scores_gemma":[0.9992042,0.000058646,0.0001405905,0.0003737333,0.0001770245,0.00004579169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008930949,0.0002054053,0.06839497,0.0003043016,0.00003111053,0.0001158754,0.0009690342,5.272454e-7,0.9193239,0.00002419628,0.00001712597,0.001682561],"study_design_scores_gemma":[0.003725755,0.001283632,0.1441447,0.0002430725,0.00003320369,0.0002072713,0.0006121607,0.0005303031,0.8475406,0.00001165316,0.001460419,0.0002072612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969478,0.000447528,0.00002817106,0.0008418149,0.00008952679,0.001477773,0.00008150272,0.0000689088,0.0000169378],"genre_scores_gemma":[0.9973834,0.00001210768,0.00004826683,0.002046721,0.00008877482,0.0002494322,0.00007420375,0.00004615335,0.00005092307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07574971,"threshold_uncertainty_score":0.8278443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797288533809126,"score_gpt":0.3212412083541497,"score_spread":0.2932683230160584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}