{"id":"W4312172964","doi":"10.3390/vaccines11010030","title":"Characterization of Systemic and Mucosal Humoral Immune Responses to an Adjuvanted Intranasal SARS-CoV-2 Protein Subunit Vaccine Candidate in Mice","year":2022,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Adjuvant; Nasal administration; Immunogenicity; Antibody; Immune system; Virology; Antigen; Immunology; Neutralizing antibody; Vaccination; Humoral immunity; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003723103,0.0008255623,0.0004532084,0.0005312379,0.0001798681,0.0003354193,0.000311706,0.0006952914,0.0007259923],"category_scores_gemma":[0.0002074042,0.0002727157,0.0004616186,0.0001365428,0.000342047,0.0004522587,0.0001776984,0.00166427,0.000402286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000374524,"about_ca_system_score_gemma":0.0002787269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004410791,"about_ca_topic_score_gemma":0.0004894842,"domain_scores_codex":[0.9997248,0.00004250146,0.00001888614,0.00007267624,0.00005191332,0.00008923361],"domain_scores_gemma":[0.9997894,0.00003794721,0.00005507178,0.00002964842,0.00003076496,0.00005714654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376283,0.000203436,0.000194285,0.00002415397,0.000005918537,0.00002680512,0.0000197492,0.0001015444,0.9981374,0.00004697102,0.00001863039,0.0009835518],"study_design_scores_gemma":[0.0001495972,0.00815706,0.006389609,0.00001570434,0.00005120645,0.0002561451,0.00005256104,0.001525909,0.9818911,0.0001064348,0.001395877,0.000008791088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946077,0.0006121031,0.00302589,0.0001124565,0.00003472824,0.0001549519,0.0005045281,0.00009708339,0.0008504433],"genre_scores_gemma":[0.9913337,0.000663049,0.003784383,0.0001837607,0.00002821826,0.0002133776,0.0009026621,0.00004060962,0.002850182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008255623,"threshold_uncertainty_score":0.002717376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797288533809126,"score_gpt":0.3212412083541497,"score_spread":0.2932683230160584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}