{"id":"W4312174119","doi":"10.3389/fonc.2022.1067321","title":"What is the future of treatment de-escalation for HPV-positive oropharyngeal cancer? A review of ongoing clinical trials","year":2022,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Université de Montréal; Western University","funders":"","keywords":"Medicine; Clinical trial; Context (archaeology); Oncology; Randomized controlled trial; Internal medicine; Surrogate endpoint; Clinical endpoint; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004386863,0.0002836321,0.007816282,0.0001372487,0.00006269872,0.000003000179,0.0001624216,0.0003618068,0.0002017035],"category_scores_gemma":[0.0006332242,0.0001652002,0.001399626,0.0003076523,0.0001582708,0.00003846521,0.00006020677,0.0004057581,3.960884e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002480876,"about_ca_system_score_gemma":0.003489329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005259053,"about_ca_topic_score_gemma":0.00005206893,"domain_scores_codex":[0.9947064,0.002360797,0.002141765,0.0003753613,0.0001618806,0.0002538056],"domain_scores_gemma":[0.994884,0.00307451,0.001565892,0.0003064336,0.0001024812,0.00006665743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003288077,0.0001900001,0.00008564336,0.03734447,0.00114776,0.000008413447,0.000554145,9.748041e-8,6.15551e-8,0.00001197997,0.05315208,0.9071766],"study_design_scores_gemma":[0.001791321,0.003849827,0.00004101494,0.05126441,0.00557579,0.0000109809,0.0006645243,0.000008762122,0.000001268185,0.00002098996,0.9366668,0.0001042542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003397133,0.9857899,0.00006940459,0.003411647,0.005326478,0.004775,0.0002723315,0.000005443069,0.000346422],"genre_scores_gemma":[6.80529e-7,0.9935607,0.001196817,0.00135148,0.001117966,0.002393541,0.000129178,0.00003014138,0.0002195346],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9070723,"threshold_uncertainty_score":0.673667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1889859874878765,"score_gpt":0.5301913802789404,"score_spread":0.3412053927910639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}