{"id":"W4312175608","doi":"10.3390/cells12010039","title":"Rescue of Misfolded Organic Cation Transporter 3 Variants","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Austrian Science Fund","keywords":"Chemical chaperone; Transporter; Organic cation transport proteins; Solute carrier family; Chemistry; Chaperone (clinical); Transport protein; Protein folding; Symporter; Cell biology; Biochemistry; Biology; Gene; Unfolded protein response; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724574,0.0004024369,0.0004625906,0.0001529596,0.0001805967,0.0003322275,0.0002758787,0.0004638777,0.001301079],"category_scores_gemma":[0.0001929236,0.0001055423,0.0003876607,0.0001702671,0.0001923925,0.0001664627,0.000319789,0.0006648268,0.0005748936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216227,"about_ca_system_score_gemma":0.0001967968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006998572,"about_ca_topic_score_gemma":0.0008600189,"domain_scores_codex":[0.9997627,0.00003915907,0.00003880249,0.00005298939,0.00006604486,0.0000402636],"domain_scores_gemma":[0.9998019,0.0000354578,0.00005074708,0.00004272701,0.00003197732,0.00003719625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000570448,0.00001955384,0.0001129128,0.00003298328,0.000006418544,0.0001406279,0.00002054057,0.00005166003,0.998633,0.00005411529,0.0000886105,0.0007825649],"study_design_scores_gemma":[0.000009012035,0.0002641485,0.002018773,0.000005335443,0.00001534075,0.0005827239,0.00004376496,0.0006356759,0.9915194,0.00004249223,0.004856922,0.000006423338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855528,0.00124985,0.008984206,0.0003109075,0.0001548467,0.00008768128,0.002120449,0.0003131883,0.001225982],"genre_scores_gemma":[0.9811146,0.001023494,0.007839856,0.0002274861,0.00002123655,0.00008778547,0.002732718,0.000159596,0.006793302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301079,"threshold_uncertainty_score":0.00435257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829904712708969,"score_gpt":0.2076888290899074,"score_spread":0.1993897819628177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}