{"id":"W4312175608","doi":"10.3390/cells12010039","title":"Rescue of Misfolded Organic Cation Transporter 3 Variants","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Austrian Science Fund","keywords":"Chemical chaperone; Transporter; Organic cation transport proteins; Solute carrier family; Chemistry; Chaperone (clinical); Transport protein; Protein folding; Symporter; Cell biology; Biochemistry; Biology; Gene; Unfolded protein response; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001399782,0.00006869123,0.0001713698,0.00005694182,0.00005510647,0.000001544462,0.00007211932,0.00003089208,0.003901828],"category_scores_gemma":[0.000001419795,0.00006236623,0.00006957741,0.0001780218,0.00001815588,0.00001904337,0.000005588147,0.000108,0.00001724726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003124903,"about_ca_system_score_gemma":0.00008443525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001818641,"about_ca_topic_score_gemma":0.00001451287,"domain_scores_codex":[0.9992897,0.00001632459,0.0001980376,0.0001445399,0.0002289085,0.0001225229],"domain_scores_gemma":[0.9996524,0.000006624881,0.00004176762,0.0002122563,0.00003314599,0.00005376422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435818,0.0001931564,0.0006905367,0.00008962507,0.00002996441,0.00006194629,0.0008540771,0.00001693015,0.9966887,0.0001913775,0.0005585146,0.0004816092],"study_design_scores_gemma":[0.00205421,0.0002542888,0.0335582,0.00004514063,0.0002173158,0.0000188396,0.0005695214,0.00005898645,0.9444623,0.0002366264,0.01837043,0.0001541314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994542,0.0001883479,0.001140441,0.0003475524,0.00043013,0.0002786026,0.00003130223,0.00003534381,0.003006252],"genre_scores_gemma":[0.9911746,0.00002863478,0.0003873138,0.0001620782,0.00003723485,0.00001122487,0.00007223037,0.00001792711,0.008108757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05222638,"threshold_uncertainty_score":0.9970087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829904712708969,"score_gpt":0.2076888290899074,"score_spread":0.1993897819628177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}