{"id":"W4312181886","doi":"10.1136/bmjopen-2022-063650","title":"Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial","year":2022,"lang":"en","type":"article","venue":"BMJ Open","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Women's College Hospital; University of Toronto","funders":"Janssen Pharmaceuticals; Janssen Scientific Affairs","keywords":"Medicine; Psoriatic arthritis; Psoriasis; Population; Internal medicine; Placebo; Arthritis; Cohort; Randomized controlled trial; Surgery; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003603638,0.0004135158,0.001995049,0.0004174944,0.0002677088,0.00002601492,0.0006234733,0.0002742216,0.0008618932],"category_scores_gemma":[0.0009051535,0.0003849868,0.0004404532,0.0006606237,0.0001063817,0.0001702688,0.000787255,0.0004371435,0.00003630035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376941,"about_ca_system_score_gemma":0.0005323944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002158215,"about_ca_topic_score_gemma":0.003867181,"domain_scores_codex":[0.9931572,0.003339221,0.001958859,0.0007265646,0.0002039046,0.0006142252],"domain_scores_gemma":[0.9961262,0.001563256,0.00161037,0.0005284825,0.0001246293,0.00004707769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9390795,0.004015716,0.03846777,0.00007572042,0.001375134,0.00003865642,0.004629808,0.0003522597,0.005304585,0.00001004734,0.0001862909,0.006464473],"study_design_scores_gemma":[0.9620843,0.001108348,0.004957251,0.0003079577,0.0004335154,0.00001870851,0.001157393,0.00006623375,0.02888951,0.00001084079,0.0005996112,0.0003663383],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6398305,0.0001265236,0.000001362276,0.00002178989,0.000278453,0.3591214,0.0001584982,0.00001800704,0.0004435028],"genre_scores_gemma":[0.6000978,0.00001725697,0.0001022814,0.000007665012,0.00003952648,0.3987114,0.0001458842,0.00002967947,0.0008485264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03973272,"threshold_uncertainty_score":0.9998602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03715669250452593,"score_gpt":0.3372630141154576,"score_spread":0.3001063216109316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}