{"id":"W4312181886","doi":"10.1136/bmjopen-2022-063650","title":"Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial","year":2022,"lang":"en","type":"article","venue":"BMJ Open","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Women's College Hospital; University of Toronto","funders":"Janssen Pharmaceuticals; Janssen Scientific Affairs","keywords":"Medicine; Psoriatic arthritis; Psoriasis; Population; Internal medicine; Placebo; Arthritis; Cohort; Randomized controlled trial; Surgery; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02156564,0.005820492,0.009563887,0.001506587,0.00270767,0.003409097,0.003260352,0.007002148,0.02517052],"category_scores_gemma":[0.01818183,0.002918851,0.006044313,0.001971507,0.003364791,0.002484457,0.001671753,0.005870512,0.006555977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003225322,"about_ca_system_score_gemma":0.01131667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949367,"about_ca_topic_score_gemma":0.003421657,"domain_scores_codex":[0.9863694,0.008177507,0.00119334,0.001692514,0.001045384,0.001521882],"domain_scores_gemma":[0.9908763,0.001658558,0.001968121,0.001416741,0.001850234,0.00223004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9785128,0.00754244,0.0005751457,0.002659265,0.0008801865,0.00007854064,0.0001412456,0.0005242786,0.001487465,0.0003865323,0.001886282,0.005325769],"study_design_scores_gemma":[0.9670905,0.02644803,0.001349754,0.0002493192,0.0005226837,0.0000293159,0.00002652318,0.0002823096,0.0002515098,0.0003103221,0.00340206,0.00003750007],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02183196,0.0008911097,0.001228841,0.0004373565,0.0005643595,0.9713085,0.002022271,0.0001254322,0.001590226],"genre_scores_gemma":[0.02209994,0.000495135,0.002225828,0.0005346625,0.0002465152,0.9727722,0.000675216,0.00001439256,0.0009359711],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02517052,"threshold_uncertainty_score":0.1140514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03715669250452593,"score_gpt":0.3372630141154576,"score_spread":0.3001063216109316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}