{"id":"W4312186750","doi":"10.3390/ijms24010133","title":"NLRP3 Inflammasome: From Pathophysiology to Therapeutic Target in Major Depressive Disorder","year":2022,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Victoria","keywords":"Inflammasome; Proinflammatory cytokine; Neuroinflammation; Pyrin domain; Antidepressant; Major depressive disorder; Medicine; Inflammation; Neuroscience; Immunology; Biology; Hippocampus; Amygdala","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003480757,0.0006628544,0.0009497078,0.001402301,0.0002068189,0.0006915297,0.0005858903,0.0009684557,0.001724469],"category_scores_gemma":[0.0004007264,0.0001864075,0.0004169237,0.001161221,0.000284012,0.0008831144,0.0004998761,0.001570792,0.001092429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003917069,"about_ca_system_score_gemma":0.0006959885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435772,"about_ca_topic_score_gemma":0.001160557,"domain_scores_codex":[0.9998969,0.00001914585,0.00002213341,0.00001799914,0.00003337552,0.00001046216],"domain_scores_gemma":[0.999872,0.00005025303,0.00002172059,0.000003228872,0.00003618096,0.00001654918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001479864,0.00008495431,0.0002028099,0.02244689,0.0001029665,0.000387658,0.00007716809,0.0003482297,0.002777206,0.002461184,0.0326073,0.9383557],"study_design_scores_gemma":[0.00005087939,0.0002883561,0.001961077,0.006995156,0.0002289165,0.003300118,0.00009185239,0.0002319772,0.0008085982,0.002957247,0.9830558,0.0000301095],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001246221,0.9990213,0.00006852388,0.0002825588,0.0001591072,0.000003205681,0.00001067936,0.000005043398,0.0003249444],"genre_scores_gemma":[0.000734065,0.9984661,0.0001267066,0.0001930663,0.0001619283,0.000005358506,0.00001840869,9.735402e-7,0.0002934056],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001724469,"threshold_uncertainty_score":0.005768955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352057114221181,"score_gpt":0.332727572551631,"score_spread":0.2975218611295129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}