{"id":"W4312188286","doi":"10.3389/fphar.2022.1086894","title":"Apigenin directly interacts with and inhibits topoisomerase 1 to upregulate CD26/DPP4 on colorectal carcinoma cells","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Apigenin; Chemistry; Topoisomerase; Camptothecin; Pharmacology; Luteolin; Naringenin; Biochemistry; Molecular biology; Biology; Flavonoid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001782771,0.0002001648,0.0004224118,0.0006107148,0.0001398787,0.00001208441,0.00008832587,0.0000504247,0.0006900504],"category_scores_gemma":[0.00001200758,0.0001870526,0.00006453154,0.0005597438,0.00009174919,0.00005648038,0.0001252945,0.0004295258,0.00001745126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900364,"about_ca_system_score_gemma":0.00008197167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004863223,"about_ca_topic_score_gemma":0.00002005954,"domain_scores_codex":[0.9985096,0.0001968545,0.0002582639,0.0004477488,0.0002256786,0.0003618167],"domain_scores_gemma":[0.9994471,0.00004509375,0.00007492515,0.0001183552,0.00003886167,0.0002756621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01092589,0.002843569,0.03498643,0.00008920603,0.0004425913,0.002420184,0.003895845,0.001269332,0.631118,0.00002792892,0.3027056,0.009275339],"study_design_scores_gemma":[0.01743866,0.003265579,0.010113,0.0001066474,0.0002831902,0.0002520949,0.001537504,0.004494718,0.9387699,0.00004068329,0.02316984,0.0005282276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947875,0.000136632,0.00008777742,0.002629053,0.0004988064,0.0005018813,0.00004256072,0.00004737684,0.001268477],"genre_scores_gemma":[0.9906319,0.00001361312,0.000840091,0.006522847,0.000103909,0.0001862613,0.00004087606,0.00002754766,0.001632979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3076518,"threshold_uncertainty_score":0.7627785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006706306795800359,"score_gpt":0.2517508129053422,"score_spread":0.2450445061095419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}