{"id":"W4312190507","doi":"10.1186/s13063-022-06897-3","title":"Clazakizumab for the treatment of chronic active antibody-mediated rejection (AMR) in kidney transplant recipients: Phase 3 IMAGINE study rationale and design","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba","funders":"CSL Behring","keywords":"Medicine; Dialysis; Internal medicine; Clinical trial; Renal function; Placebo; Transplantation; Kidney transplantation; Surrogate endpoint; Phases of clinical research; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007174696,0.0001328756,0.0005066525,0.0001386855,0.0001293849,0.000007728362,0.00003720209,0.00002180842,0.0001578223],"category_scores_gemma":[0.00009999809,0.00008147352,0.0001075916,0.0001957287,0.00002677649,0.00005320451,0.000003134563,0.00005341843,0.000001109714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716694,"about_ca_system_score_gemma":0.0001873427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001607379,"about_ca_topic_score_gemma":0.00002038674,"domain_scores_codex":[0.9985357,0.0003878687,0.00052015,0.0002117886,0.0002179753,0.0001265131],"domain_scores_gemma":[0.9982135,0.001363029,0.0001900709,0.0001329294,0.00004314668,0.00005737576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3448889,0.09403447,0.09272816,0.000789916,0.0110128,0.0006088035,0.05615483,0.003671614,0.2495047,0.0003294717,0.0005101399,0.1457662],"study_design_scores_gemma":[0.643016,0.09963622,0.158819,0.0006716897,0.007736693,0.0002158142,0.004030888,0.01026293,0.06880908,0.0003261747,0.005870121,0.0006052979],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969875,0.001548876,0.007894597,0.001132142,0.0005137946,0.01680328,0.002167471,0.00003199878,0.00003278004],"genre_scores_gemma":[0.9954908,0.00157304,0.0002388705,0.00005199686,0.00007358291,0.001498339,0.0008502468,0.00001455865,0.0002085123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2981271,"threshold_uncertainty_score":0.3322394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1216137892168281,"score_gpt":0.4229404489969131,"score_spread":0.301326659780085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}