{"id":"W4312190507","doi":"10.1186/s13063-022-06897-3","title":"Clazakizumab for the treatment of chronic active antibody-mediated rejection (AMR) in kidney transplant recipients: Phase 3 IMAGINE study rationale and design","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba","funders":"CSL Behring","keywords":"Medicine; Dialysis; Internal medicine; Clinical trial; Renal function; Placebo; Transplantation; Kidney transplantation; Surrogate endpoint; Phases of clinical research; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009164235,0.002373384,0.003205822,0.0007523833,0.001002919,0.001773024,0.002152907,0.002486906,0.008601028],"category_scores_gemma":[0.003339106,0.001037166,0.002889805,0.0006924773,0.001946848,0.001530695,0.0009332862,0.003594624,0.001983013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009874979,"about_ca_system_score_gemma":0.00491483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005288387,"about_ca_topic_score_gemma":0.001381703,"domain_scores_codex":[0.9973934,0.00160043,0.0001304359,0.0002881908,0.0002520604,0.0003355522],"domain_scores_gemma":[0.9980569,0.000326755,0.0003536236,0.0002006396,0.0002364682,0.0008255509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8514357,0.04730754,0.0060174,0.003672585,0.00217306,0.0004380748,0.0002189206,0.002068307,0.02305101,0.002222228,0.01039323,0.05100193],"study_design_scores_gemma":[0.8191325,0.1583281,0.003695178,0.0002740874,0.001144752,0.0002838258,0.00004629047,0.00120789,0.002754127,0.00116001,0.01191802,0.00005530394],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.6031304,0.0183549,0.01667518,0.006385547,0.001800572,0.3216601,0.01414761,0.0008349493,0.0170108],"genre_scores_gemma":[0.6623709,0.007001689,0.02564305,0.009336672,0.00172483,0.2794204,0.006866081,0.0001323255,0.007504134],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.009164235,"threshold_uncertainty_score":0.04846567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1216137892168281,"score_gpt":0.4229404489969131,"score_spread":0.301326659780085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}