{"id":"W4312192520","doi":"10.1016/j.eclinm.2022.101792","title":"Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not","year":2022,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Balnaves Foundation; Department of Health, State Government of Victoria; Queensland Health; Ministry of Health, British Columbia; Gilead Sciences; U.S. Department of Health and Human Services","keywords":"Medicine; Cognitive decline; Context (archaeology); Cognition; Human immunodeficiency virus (HIV); Antiretroviral therapy; Cognitive impairment; Cognitive aging; Disease; Gerontology; Dementia; Immunology; Viral load; Psychiatry; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001713821,0.0003680646,0.0008254073,0.0003162487,0.0004512838,0.00002169077,0.000303163,0.0001805882,0.003625539],"category_scores_gemma":[0.001465017,0.0003185533,0.0001325908,0.0003721698,0.0005775799,0.0001149046,0.001158361,0.001286522,0.0002705251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130209,"about_ca_system_score_gemma":0.0002216529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204289,"about_ca_topic_score_gemma":0.0003651729,"domain_scores_codex":[0.996353,0.0008451108,0.0009141464,0.0007518373,0.0002454168,0.0008904877],"domain_scores_gemma":[0.9960111,0.003032696,0.0003082201,0.000278846,0.000203549,0.000165597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009286013,0.002581413,0.969016,0.00007123014,0.0007109892,0.001874774,0.002325983,0.000006313493,0.00369944,0.00005769808,0.004296215,0.006073967],"study_design_scores_gemma":[0.06845246,0.008110476,0.8778154,0.0004854919,0.0004399603,0.0003705159,0.02263811,0.0001782208,0.01038452,0.0003770184,0.009953198,0.0007946774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846064,0.002046736,0.00008030832,0.009946044,0.0002629184,0.0009011229,0.001376552,0.00008245186,0.0006974216],"genre_scores_gemma":[0.9901645,0.0003051267,0.00003684051,0.004503055,0.0001144276,0.0002082416,0.002182167,0.00003941056,0.002446224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09120062,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02390912362529476,"score_gpt":0.3168295859247431,"score_spread":0.2929204622994483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}