{"id":"W4312192520","doi":"10.1016/j.eclinm.2022.101792","title":"Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not","year":2022,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Balnaves Foundation; Department of Health, State Government of Victoria; Queensland Health; Ministry of Health, British Columbia; Gilead Sciences; U.S. Department of Health and Human Services","keywords":"Medicine; Cognitive decline; Context (archaeology); Cognition; Human immunodeficiency virus (HIV); Antiretroviral therapy; Cognitive impairment; Cognitive aging; Disease; Gerontology; Dementia; Immunology; Viral load; Psychiatry; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004664137,0.0003170895,0.000560993,0.0008838784,0.0003921149,0.00110765,0.0005987292,0.0003733497,0.001177365],"category_scores_gemma":[0.01483083,0.0001869928,0.0004943004,0.0009934381,0.0008545133,0.0009070366,0.001113035,0.0007354611,0.0001674949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005532657,"about_ca_system_score_gemma":0.001241644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004916269,"about_ca_topic_score_gemma":0.01221209,"domain_scores_codex":[0.9978237,0.0009513543,0.0002611971,0.0003303221,0.0005072157,0.0001261687],"domain_scores_gemma":[0.9924851,0.002046792,0.003925206,0.0005398757,0.0006762239,0.0003267674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003103378,0.0001070305,0.9676597,0.000178524,0.0002755696,0.0001517586,0.0003160641,0.000313779,0.0003383918,0.0002502358,0.0003629798,0.02973554],"study_design_scores_gemma":[0.00001422543,0.0004238699,0.9956186,0.00008380759,0.0001150529,0.0004263173,0.0002603059,0.001066833,0.0003291172,0.000848587,0.0008046422,0.000008523138],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904614,0.002271228,0.003048868,0.0005457536,0.00003475692,0.00009248327,0.0009255007,0.00004147029,0.00257853],"genre_scores_gemma":[0.9983642,0.0003331401,0.0007637054,0.00007810992,0.00002206131,0.00002788133,0.0002552672,0.000003014004,0.0001527286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004916269,"threshold_uncertainty_score":0.02466661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02390912362529476,"score_gpt":0.3168295859247431,"score_spread":0.2929204622994483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}