{"id":"W4312194527","doi":"10.1002/bies.202200196","title":"Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization","year":2022,"lang":"en","type":"article","venue":"BioEssays","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Effector; PTEN; Phosphatidylinositol; Tensin; Phosphatase; Kinase; Endosome; Compartmentalization (fire protection); Scaffold protein; Signal transduction; Phosphorylation; Endocytic cycle; Caveolae; Biology; PI3K/AKT/mTOR pathway; Lipid raft; Chemistry; Biochemistry; Endocytosis; Enzyme; Intracellular; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344072,0.00007579443,0.0001118888,0.00002821668,0.00006296865,0.000003754091,0.00008876345,0.00004000488,0.0001369052],"category_scores_gemma":[0.000003191846,0.00008403976,0.00005347365,0.00008621124,0.00003025122,0.00000211211,0.00002009181,0.00004100585,7.519438e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001417084,"about_ca_system_score_gemma":0.0000195543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004809405,"about_ca_topic_score_gemma":0.00001252873,"domain_scores_codex":[0.9993498,0.00005433026,0.0001883534,0.0001678238,0.0001291135,0.0001106007],"domain_scores_gemma":[0.9997647,0.00000493766,0.000069514,0.0001149431,0.00001861783,0.00002724152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292152,0.0001524758,0.02006617,0.0000152636,0.00001330363,0.000002593845,0.00003766632,0.0007722575,0.9784703,0.0001348261,0.0001450295,0.00006092698],"study_design_scores_gemma":[0.001279316,0.0001698723,0.0004642398,0.000004627135,0.00001414661,0.000001815068,0.00009241417,0.0006319429,0.9768296,0.00001345315,0.02039467,0.0001038631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857875,0.001390493,0.01208484,0.00004925579,0.0001142543,0.0001868101,0.0001429316,0.000006370774,0.0002376057],"genre_scores_gemma":[0.9948396,0.00003368763,0.00004192519,0.00008616413,0.00002268092,0.00002715197,0.004837973,0.00001020953,0.000100624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02024964,"threshold_uncertainty_score":0.3427042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006106935743892367,"score_gpt":0.2058609720787627,"score_spread":0.1997540363348703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}