{"id":"W4312194527","doi":"10.1002/bies.202200196","title":"Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization","year":2022,"lang":"en","type":"article","venue":"BioEssays","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Effector; PTEN; Phosphatidylinositol; Tensin; Phosphatase; Kinase; Endosome; Compartmentalization (fire protection); Scaffold protein; Signal transduction; Phosphorylation; Endocytic cycle; Caveolae; Biology; PI3K/AKT/mTOR pathway; Lipid raft; Chemistry; Biochemistry; Endocytosis; Enzyme; Intracellular; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280729,0.000179007,0.0001431942,0.0001076806,0.0002000096,0.000514289,0.0002401615,0.0002215232,0.0009464939],"category_scores_gemma":[0.0001877693,0.0001454197,0.0001607362,0.0001363106,0.0003064817,0.0004032099,0.0003338407,0.0003755032,0.0003405326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005441889,"about_ca_system_score_gemma":0.0003059635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981467,"about_ca_topic_score_gemma":0.0007273357,"domain_scores_codex":[0.9998966,0.000009888086,0.000006415184,0.00002588099,0.00003630067,0.00002482075],"domain_scores_gemma":[0.9999212,0.0000217348,0.0000254381,0.00001079283,0.000009175586,0.00001173847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005432584,0.00001411743,0.00009871722,0.00003818894,0.000002678782,0.00002803683,0.00001202045,0.0005231251,0.992968,0.002514704,0.0001315792,0.003614378],"study_design_scores_gemma":[0.00001904379,0.00006711904,0.0008468498,0.000005003101,0.000005187133,0.00007281743,0.00002673832,0.008471664,0.9839233,0.0008355585,0.00571812,0.00000869409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471162,0.003784145,0.03423674,0.0006464347,0.0001506362,0.00004296802,0.0002677132,0.000429797,0.01332534],"genre_scores_gemma":[0.9925779,0.001315941,0.004390465,0.00007435141,0.00001825303,0.00003531922,0.00006620826,0.00002617598,0.001495395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009464939,"threshold_uncertainty_score":0.00394839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006106935743892367,"score_gpt":0.2058609720787627,"score_spread":0.1997540363348703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}